CRTC3

Gene Symbol CRTC3
Entrez Gene 64784
Alt Symbol TORC-3, TORC3
Species Human
Gene Type protein-coding
Description CREB regulated transcription coactivator 3
Other Description CREB-regulated transcription coactivator 3|transducer of regulated CREB protein 3|transducer of regulated cAMP response element-binding protein (CREB) 3|transducer of regulated cAMP response element-binding protein 3
Swissprots Q6UUV7 Q6DK61 Q6DK62 Q9H6U2 Q8NF38
Accessions Q6UUV7 AI969212 AK024981 AK025521 BAB15160 AK074170 BAB84996 AK090443 BAC03424 AK225300 AL360259 AY360173 AAQ98858 BC019060 BC074730 AAH74730 BC074731 AAH74731 BP238198 BP365179 BQ945777 CN298837 DB288138 HY057135 HY109267 HY180993 XM_005254968 XP_005255025 XM_011521906 XP_011520208 NM_001042574 NP_001036039 NM_022769 NP_073606
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}.
Subcellular Location Nucleus. Cytoplasm. Note=Appears to be mainly nuclear.
Tissue Specificity Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach. {ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:16980408}.
Top Pathways HTLV-I infection

TORC3 CRISPR/Cas9 KO Plasmid (h) - sc-413035 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC3 HDR Plasmid (h) - sc-413035-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC3 Double Nickase Plasmid (h) - sc-413035-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC3 Double Nickase Plasmid (h2) - sc-413035-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC3 CRISPR Activation Plasmid (h) - sc-413035-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC3 CRISPR Activation Plasmid (h2) - sc-413035-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC3 Lentiviral Activation Particles (h) - sc-413035-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC3 Lentiviral Activation Particles (h2) - sc-413035-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TORC3 siRNA (h) - sc-90206 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TORC3 shRNA Plasmid (h) - sc-90206-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TORC3 shRNA (h) Lentiviral Particles - sc-90206-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU004371 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6599 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6599 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13890 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr13890

CRTC3 siRNA (Human) - CRJ2089 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CRTC3 - MBS829160 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CRTC3 (NM_022769.4) - SHH269841 from Creative biogene

Category siRNA
Species Reactivities Human

CRTC3 shRNA Plasmid (Human) - CHJ2089 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CRTC3 miRNA 3'UTR clone - MiUTR4H-TG02366 from Creative biogene

Species Reactivities Human
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