CRTC3

Gene Symbol CRTC3
Entrez Gene 64784
Alt Symbol TORC-3, TORC3
Species Human
Gene Type protein-coding
Description CREB regulated transcription coactivator 3
Other Description CREB-regulated transcription coactivator 3|transducer of regulated CREB protein 3|transducer of regulated cAMP response element-binding protein (CREB) 3|transducer of regulated cAMP response element-binding protein 3
Swissprots Q6UUV7 Q6DK61 Q6DK62 Q9H6U2 Q8NF38
Accessions Q6UUV7 AI969212 AK024981 AK025521 BAB15160 AK074170 BAB84996 AK090443 BAC03424 AK225300 AL360259 AY360173 AAQ98858 BC019060 BC074730 AAH74730 BC074731 AAH74731 BP238198 BP365179 BQ945777 CN298837 DB288138 HY057135 HY109267 HY180993 XM_005254968 XP_005255025 XM_011521906 XP_011520208 NM_001042574 NP_001036039 NM_022769 NP_073606
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}.
Subcellular Location Nucleus. Cytoplasm. Note=Appears to be mainly nuclear.
Tissue Specificity Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach. {ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:16980408}.
Top Pathways HTLV-I infection

Human CRTC3 protein fragment - ab153493 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153493 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human TORC3/CRTC3 Protein - H00064784-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

CRTC3 - H00064784-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

CRTC3 - H00064784-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

Recombinant CREB Regulated Transcription Coactivator 3 (CRTC3) - RPE001Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

Recombinant CREB Regulated Transcription Coactivator 3 (CRTC3) - RPE001Hu01 from Cloud-clone

Category Protein
Source E.coli
Species Human

Recombinant Human CREB-regulated transcription coactivator 3(CRTC3) - CSB-YP747623HU CSB-EP747623HU CSB-BP747623HU CSB-MP747623HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CREB Regulated Transcription Coactivator 3 Protein (Recombinant) - abx166752 from Abbexa

Category Protein
Source Human
Species Human

TORC3/CRTC3 Recombinant Protein Antigen - NBP1-83615PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CRTC3-Antibody-C-term-Blocking-Peptide - BP6633b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CRTC3 Peptide, Human - M34GP03667H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Recombinant CREB Regulated Transcription Coactivator 3 (CRTC3) - RPU52243 from Biomatik

Category Protein
Prices $185.00, $378.00, $578.00, $688.80
Sizes 10 µg, 50 µg, 100 µg, 200 µg
Source E.coli
Species Human

CRTC3 Recombinant Protein (OPCD02438) - OPCD02438 from Aviva Systems Biology

Category Protein
Source E.coli
Species Human

CREB Regulated Transcription Coactivator 3, Recombinant Protein - MBS2031302 from MyBioSource

Category Protein
Prices $185.00, $380.00, $585.00
Sizes 10 µg, 50 µg, 100 µg
Source Prokaryotic expression
Species Human

CREB-regulated transcription coactivator 3 (CRTC3), Recombinant Protein - MBS1425776 from MyBioSource

Category Protein
Prices $1,415.00, $1,415.00, $1,640.00, $1,640.00, $2,390.00, $2,390.00, $2,830.00, $2,830.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

TORC3/CRTC3 Recombinant Protein Antigen - NBP2-56127PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human
Search more