CRTC3

Gene Symbol	CRTC3
Entrez Gene	64784
Alt Symbol	TORC-3, TORC3
Species	Human
Gene Type	protein-coding
Description	CREB regulated transcription coactivator 3
Other Description	CREB-regulated transcription coactivator 3\|transducer of regulated CREB protein 3\|transducer of regulated cAMP response element-binding protein (CREB) 3\|transducer of regulated cAMP response element-binding protein 3
Swissprots	Q6UUV7 Q6DK61 Q6DK62 Q9H6U2 Q8NF38
Accessions	Q6UUV7 AI969212 AK024981 AK025521 BAB15160 AK074170 BAB84996 AK090443 BAC03424 AK225300 AL360259 AY360173 AAQ98858 BC019060 BC074730 AAH74730 BC074731 AAH74731 BP238198 BP365179 BQ945777 CN298837 DB288138 HY057135 HY109267 HY180993 XM_005254968 XP_005255025 XM_011521906 XP_011520208 NM_001042574 NP_001036039 NM_022769 NP_073606
Function	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269\|PubMed:14506290, ECO:0000269\|PubMed:15454081, ECO:0000269\|PubMed:15466468, ECO:0000269\|PubMed:16817901, ECO:0000269\|PubMed:16980408, ECO:0000269\|PubMed:17210223, ECO:0000269\|PubMed:17644518}.
Subcellular Location	Nucleus. Cytoplasm. Note=Appears to be mainly nuclear.
Tissue Specificity	Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach. {ECO:0000269\|PubMed:14536081, ECO:0000269\|PubMed:16980408}.
Top Pathways	HTLV-I infection

TORC3/CRTC3 Antibody - 2768 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from 293 and PANC-1 cells using TORC3/CRTC3 Antibody.

TORC3/CRTC3 (C35G4) Rabbit mAb - 2720 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	C35G4

Western blot analysis of extracts from MCF7, LN18, and SK-N-MC cells using TORC3/CRTC3 (C35G4) Rabbit mAb.

TORC3 (A-12) - sc-390712 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

TORC3 (A-12): sc-390712. Western blot analysis of TORC3 expression in non-transfected: sc-117752 (A) and mouse TORC3 transfected: sc-127688 (B) 293T whole cell lysates.

TORC3 (C-19) - sc-139571 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

TORC3 (C-19): sc-139571. Western blot analysis of TORC3 expression in non-transfected: sc-117752 (A) and mouse TORC3 transfected: sc-127688 (B) 293T whole cell lysates.

TORC3 (S-17) - sc-139569 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

Anti-CRTC3 antibody [5G9] - ab110033 from Abcam

Host	Mouse
Clonality	Monoclonal
Clone	5G9

All lanes : Anti-CRTC3 antibody [5G9] (ab110033) at 1/500 dilutionLane 1 : Hela cell lysateLane 2 : Jurkat cell lysateLane 3 : Cos7 cell lysateLane 4 : MCF7 cell lysate

Anti-CRTC3 antibody [EPR3440] - ChIP Grade - ab91654 from Abcam

Prices	$391.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3440

ChIP analysis using ab91654 binding CRTC3 in Human neuroblastoma cells. Cells were cross-linked for 10 minutes with 1% formaldehyde. Samples were incubated with primary antibody (0.2µg/10^6 cells) for 12 hours at 4°C. Protein binding was detected using real-time PCR.Positive control: GAPDH.Negative Control: Primers for region not expressed. See Abreview

Anti-CRTC3 Antibody (aa569-619) - LS-C289423 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Detection of Human TORC3 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-TORC3 used at a dilution of 1:200 (1 ug/ml). Detection: DAB.

Anti-CRTC3 Antibody (aa569-619) - LS-C286887 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CRTC3 Antibody (Internal, clone EPR3440) - LS-C105612 from LifeSpan Bioscience

Host	Rabbit
Clonality	Monoclonal
Clone	EPR3440

IHC of paraffin-embedded human tonsils using anti-TorC3 antibody (LS-C105612).

Anti-CRTC3 Antibody (clone 5G9) IHC-plus™ - LS-B11713 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	5G9

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

TORC3/CRTC3 Antibody (5G9) - NBP2-37635 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	5G9

TORC3/CRTC3 Antibody - NBP1-83615 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

TORC3/CRTC3 Antibody - NBP1-46832 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

TORC3/CRTC3 Antibody (1D9) - H00064784-M05-100ug from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1D9

CRTC3/TORC3 Polyclonal Antibody - bs-12950R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CRTC3/TORC3 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12950R-A350 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CRTC3/TORC3 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12950R-A488 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CRTC3/TORC3 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12950R-A555 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CRTC3/TORC3 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12950R-A647 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CRTC3/TORC3 Polyclonal Antibody, Cy3 Conjugated - bs-12950R-Cy3 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CRTC3/TORC3 Polyclonal Antibody, Cy5 Conjugated - bs-12950R-Cy5 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CRTC3/TORC3 Polyclonal Antibody, Cy5.5 Conjugated - bs-12950R-Cy5.5 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CRTC3/TORC3 Polyclonal Antibody, Cy7 Conjugated - bs-12950R-Cy7 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CRTC3/TORC3 Polyclonal Antibody, FITC Conjugated - bs-12950R-FITC from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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