| Gene Symbol |
CTU1
|
| Entrez Gene |
90353
|
| Alt Symbol |
ATPBD3, NCS6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytosolic thiouridylase subunit 1
|
| Other Description |
ATP binding domain 3|ATP-binding domain-containing protein 3|cancer-associated gene protein|cancer-associated protein|cytoplasmic tRNA 2-thiolation protein 1|cytoplasmic tRNA adenylyltransferase 1|cytosolic thiouridylase subunit 1 homolog
|
| Swissprots |
Q96GZ7 A8K558 Q7Z7A3
|
| Accessions |
AAP42277 EAW71984 Q7Z7A3 AK291173 BAF83862 BC009037 AAH09037 BX440723 NM_145232 NP_660275
|
| Function |
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03053, ECO:0000269|PubMed:19017811}.
|
| Subcellular Location |
Cytoplasm.
|
| Top Pathways |
Sulfur relay system
|