| Gene Symbol |
PPM1A
|
| Entrez Gene |
5494
|
| Alt Symbol |
PP2C-ALPHA, PP2CA, PP2Calpha
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase, Mg2+/Mn2+ dependent, 1A
|
| Other Description |
protein phosphatase 1A|protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
|
| Swissprots |
J3KNM0 O75551 B5BU11 P35813
|
| Accessions |
EAW80774 EAW80775 EAW80776 EAW80777 P35813 AB451247 BAG70061 AB451371 BAG70185 AF070670 AAC28354 AI076736 AK097843 AK124299 AK308225 AK313337 BAG36141 AY236965 AAQ20086 BC026691 AAH26691 BC063243 AAH63243 BF511118 BQ876369 CA427296 CB156710 DA439296 DQ891766 ABM82692 DQ894950 ABM85876 L32169 S87759 AAB21784 XM_005267779 XP_005267836 XM_005267781 XP_005267838 XM_006720179 XP_006720242 XM_011536857 XP_011535159 XM_011536858 XP_011535160 XM_011536859 XP_011535161 XM_011536860 XP_011535162 XM_011536861 XP_011535163 XM_011536862 XP_011535164 XM_011536863 XP_011535165 XM_011536864 XP_011535166 XM_011536865 XP_011535167 XM_011536866 XP_011535168 XM_011536867 XP_011535169 XM_011536868 XP_011535170 XM_011536869 XP_011535171 XM_011536870 XP_011535172 XM_011536871 XP_011535173 XM_011536872 XP_011535174 XM_011536873 XP_011535175 XM_011536874 XP_011535176 XM_011536875 XP_011535177 XM_011536876 XP_011535178 XM_011536877 XP_011535179 XM_011536878 XP_011535180 XM_011536879 XP_011535181 XM_011536880 XP_011535182 XM_011536881 XP_011535183 XM_011536882 XP_011535184 XM_011536883 XP_011535185 XM_011536884 XP_011535186 NM_021003 NP_066283 NM_177951 NP_808820 NM_177952 NP_808821
|
| Function |
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}.
|
| Subcellular Location |
Nucleus. Cytoplasm, cytosol. Membrane {ECO:0000250}. Note=Weakly associates at the membrane and N- myristoylation mediates the membrane localization. {ECO:0000250}.
|
| Top Pathways |
MAPK signaling pathway
|