PPM1A

Gene Symbol	PPM1A
Entrez Gene	5494
Alt Symbol	PP2C-ALPHA, PP2CA, PP2Calpha
Species	Human
Gene Type	protein-coding
Description	protein phosphatase, Mg2+/Mn2+ dependent, 1A
Other Description	protein phosphatase 1A|protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
Swissprots	J3KNM0 O75551 B5BU11 P35813
Accessions	EAW80774 EAW80775 EAW80776 EAW80777 P35813 AB451247 BAG70061 AB451371 BAG70185 AF070670 AAC28354 AI076736 AK097843 AK124299 AK308225 AK313337 BAG36141 AY236965 AAQ20086 BC026691 AAH26691 BC063243 AAH63243 BF511118 BQ876369 CA427296 CB156710 DA439296 DQ891766 ABM82692 DQ894950 ABM85876 L32169 S87759 AAB21784 XM_005267779 XP_005267836 XM_005267781 XP_005267838 XM_006720179 XP_006720242 XM_011536857 XP_011535159 XM_011536858 XP_011535160 XM_011536859 XP_011535161 XM_011536860 XP_011535162 XM_011536861 XP_011535163 XM_011536862 XP_011535164 XM_011536863 XP_011535165 XM_011536864 XP_011535166 XM_011536865 XP_011535167 XM_011536866 XP_011535168 XM_011536867 XP_011535169 XM_011536868 XP_011535170 XM_011536869 XP_011535171 XM_011536870 XP_011535172 XM_011536871 XP_011535173 XM_011536872 XP_011535174 XM_011536873 XP_011535175 XM_011536874 XP_011535176 XM_011536875 XP_011535177 XM_011536876 XP_011535178 XM_011536877 XP_011535179 XM_011536878 XP_011535180 XM_011536879 XP_011535181 XM_011536880 XP_011535182 XM_011536881 XP_011535183 XM_011536882 XP_011535184 XM_011536883 XP_011535185 XM_011536884 XP_011535186 NM_021003 NP_066283 NM_177951 NP_808820 NM_177952 NP_808821
Function	Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}.
Subcellular Location	Nucleus. Cytoplasm, cytosol. Membrane {ECO:0000250}. Note=Weakly associates at the membrane and N- myristoylation mediates the membrane localization. {ECO:0000250}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PPM1A full length protein - ab128560 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human PPM1A full length protein - ab51205 from Abcam Category Protein Prices $195.00, $588.00 Sizes 100 µg, 500 µg Source E. coli Species Human

PPM1A / PP2CA Antibody Blocking Peptide - LS-E3167 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPM1A / PP2CA Antibody Blocking Peptide - LS-E21103 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PP2C alpha/PPM1A Protein - H00005494-P01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

Recombinant Human PP2C alpha/PPM1A Protein - NBC1-18383 from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µg Source E.coli Species Human

PP2C alpha/PPM1A Recombinant Protein - P3446 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

PPM1A-Antibody-Blocking-Peptide - BP14313a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PP2A alpha + PP2A beta blocking peptide - GTX89984-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Rabbit, Bovine

Recombinant Human PP2C alpha/PPM1A, CF - 4150-PP-050 from R&D Systems Category Protein Source E. coli-derived, Gly2-Lys324, with a C-terminal 6-His tag

PPM1A Protein (OPPA01136) - OPPA01136 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human PPM1A protein - orb80862 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Species Human

Human PPM1A protein (His Tag) - orb139509 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source E. coli Species Human

PP2C alpha protein (His tag) - 80R-1004 from Fitzgerald Category Protein Prices $180.00 Sizes 100 µg Source E.coli

PPM1A Blocking Peptide - 33R-2464 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Protein phosphatase 1A / PPM1A (1-382, His-tag) - SA6016 from Acris Antibodies Category Protein Prices $270.00 Sizes 100 µg Source E. coli Species Human

Protein phosphatase 1A / PPM1A (1-382, His-tag) - SA6016X from Acris Antibodies Category Protein Prices $585.00 Sizes 500 µg Source E. coli Species Human

Protein phosphatase 1A / PPM1A - H00005494-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

Protein phosphatase 1A / PPM1A - P3446 from Acris Antibodies Category Protein Prices $430.00 Sizes 100 µg Species Human

Protein Phosphatase 1A Alpha Isoform, Human Recombinant - 228-11294-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human PPM1A - 228-11294-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human PPM1A - 228-11294-3 from RayBiotech Category Protein Prices $1,950.00 Sizes 3 µg Source Escherichia Coli. Species Human

His-PP2Calpha(His-tagging Protein phosphatase 2C), Human, Recombinant, E.coli - 01-2220 from ARP American Research Products Category Protein Prices $139.00, $299.00, $639.00 Sizes 20 µg, 100 µg, 500 µg Source E.coli Species Human

Protein Phosphatase 1A, PPM1A, Human, Recombinant - 19-C161 from ARP American Research Products Category Protein Prices $109.00 Sizes 10 µg Source E. coli Species Human

PPM1A fusion protein - ag3645 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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