PPM1A

Gene Symbol PPM1A
Entrez Gene 5494
Alt Symbol PP2C-ALPHA, PP2CA, PP2Calpha
Species Human
Gene Type protein-coding
Description protein phosphatase, Mg2+/Mn2+ dependent, 1A
Other Description protein phosphatase 1A|protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
Swissprots J3KNM0 O75551 B5BU11 P35813
Accessions EAW80774 EAW80775 EAW80776 EAW80777 P35813 AB451247 BAG70061 AB451371 BAG70185 AF070670 AAC28354 AI076736 AK097843 AK124299 AK308225 AK313337 BAG36141 AY236965 AAQ20086 BC026691 AAH26691 BC063243 AAH63243 BF511118 BQ876369 CA427296 CB156710 DA439296 DQ891766 ABM82692 DQ894950 ABM85876 L32169 S87759 AAB21784 XM_005267779 XP_005267836 XM_005267781 XP_005267838 XM_006720179 XP_006720242 XM_011536857 XP_011535159 XM_011536858 XP_011535160 XM_011536859 XP_011535161 XM_011536860 XP_011535162 XM_011536861 XP_011535163 XM_011536862 XP_011535164 XM_011536863 XP_011535165 XM_011536864 XP_011535166 XM_011536865 XP_011535167 XM_011536866 XP_011535168 XM_011536867 XP_011535169 XM_011536868 XP_011535170 XM_011536869 XP_011535171 XM_011536870 XP_011535172 XM_011536871 XP_011535173 XM_011536872 XP_011535174 XM_011536873 XP_011535175 XM_011536874 XP_011535176 XM_011536875 XP_011535177 XM_011536876 XP_011535178 XM_011536877 XP_011535179 XM_011536878 XP_011535180 XM_011536879 XP_011535181 XM_011536880 XP_011535182 XM_011536881 XP_011535183 XM_011536882 XP_011535184 XM_011536883 XP_011535185 XM_011536884 XP_011535186 NM_021003 NP_066283 NM_177951 NP_808820 NM_177952 NP_808821
Function Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}.
Subcellular Location Nucleus. Cytoplasm, cytosol. Membrane {ECO:0000250}. Note=Weakly associates at the membrane and N- myristoylation mediates the membrane localization. {ECO:0000250}.
Top Pathways MAPK signaling pathway

PP2Cα CRISPR/Cas9 KO Plasmid (h) - sc-403960 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PP2Cα HDR Plasmid (h) - sc-403960-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PP2Cα Double Nickase Plasmid (h) - sc-403960-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PP2Cα Double Nickase Plasmid (h2) - sc-403960-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PP2Cα CRISPR Activation Plasmid (h) - sc-403960-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PP2Cα CRISPR Activation Plasmid (h2) - sc-403960-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PP2Cα Lentiviral Activation Particles (h) - sc-403960-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PP2Cα Lentiviral Activation Particles (h2) - sc-403960-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PP2Cα siRNA (h) - sc-45214 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PP2Cα shRNA Plasmid (h) - sc-45214-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PP2Cα shRNA (h) Lentiviral Particles - sc-45214-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PP2C alpha/PPM1A RNAi - H00005494-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

PP2C alpha/PPM1A RNAi - H00005494-R03 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU075881 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® Human Phosphatase - SIHP0475 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0476 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0477 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP1012 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN17240 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17240 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07582 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07582

PPM1A siRNA (Human) - CRH3680 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PP2C alpha/PPM1A RNAi - H00005494-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human PPM1A (NM_177952.2) - SHH380784 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PPM1A(NM_177952.2) - SHR105790 from Creative biogene

Category siRNA
Species Reactivities Human
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