PPM1A

Gene Symbol PPM1A
Entrez Gene 5494
Alt Symbol PP2C-ALPHA, PP2CA, PP2Calpha
Species Human
Gene Type protein-coding
Description protein phosphatase, Mg2+/Mn2+ dependent, 1A
Other Description protein phosphatase 1A|protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
Swissprots J3KNM0 O75551 B5BU11 P35813
Accessions EAW80774 EAW80775 EAW80776 EAW80777 P35813 AB451247 BAG70061 AB451371 BAG70185 AF070670 AAC28354 AI076736 AK097843 AK124299 AK308225 AK313337 BAG36141 AY236965 AAQ20086 BC026691 AAH26691 BC063243 AAH63243 BF511118 BQ876369 CA427296 CB156710 DA439296 DQ891766 ABM82692 DQ894950 ABM85876 L32169 S87759 AAB21784 XM_005267779 XP_005267836 XM_005267781 XP_005267838 XM_006720179 XP_006720242 XM_011536857 XP_011535159 XM_011536858 XP_011535160 XM_011536859 XP_011535161 XM_011536860 XP_011535162 XM_011536861 XP_011535163 XM_011536862 XP_011535164 XM_011536863 XP_011535165 XM_011536864 XP_011535166 XM_011536865 XP_011535167 XM_011536866 XP_011535168 XM_011536867 XP_011535169 XM_011536868 XP_011535170 XM_011536869 XP_011535171 XM_011536870 XP_011535172 XM_011536871 XP_011535173 XM_011536872 XP_011535174 XM_011536873 XP_011535175 XM_011536874 XP_011535176 XM_011536875 XP_011535177 XM_011536876 XP_011535178 XM_011536877 XP_011535179 XM_011536878 XP_011535180 XM_011536879 XP_011535181 XM_011536880 XP_011535182 XM_011536881 XP_011535183 XM_011536882 XP_011535184 XM_011536883 XP_011535185 XM_011536884 XP_011535186 NM_021003 NP_066283 NM_177951 NP_808820 NM_177952 NP_808821
Function Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}.
Subcellular Location Nucleus. Cytoplasm, cytosol. Membrane {ECO:0000250}. Note=Weakly associates at the membrane and N- myristoylation mediates the membrane localization. {ECO:0000250}.
Top Pathways MAPK signaling pathway

PP2C-α (D18C10) XP ® Rabbit mAb - 3549 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D18C10
Western blot analysis of extracts from various cell lines using PP2C-α (D18C10) XP ® Rabbit mAb.

PP2Cα (L-18) - sc-32402 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PP2Cα (L-18): sc-32402. Western blot analysis of PP2Cα/β expression in non-transfected: sc-117752 (A) and human PP2Cα/β transfected: sc-116262 (B) 293T whole cell lysates.

PP2Cα (N-13) - sc-32401 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PP2Cα (N-13): sc-32401. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic staining of glandular cells.

PP2Cα (p6c7) - sc-56956 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
PP2Cα (p6c7): sc-56956. Western blot analysis of PP2Cα expression in non-transfected 293T: sc-117752 (A), human PP2Cα transfected 293T: sc-113626 (B) and HeLa (C) whole cell lysates.

PP2Cα (6D708) - sc-71922 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
PP2Cα (6D708): sc-71922. Western blot analysis of PP2Cα expression in non-transfected 293T: sc-117752 (A), human PP2Cα transfected 293T: sc-113626 (B) and HeLa (C) whole cell lysates.

PP2Cα/β (D-8) - sc-166662 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PP2Cα/β (D-8): sc-166662. Western blot analysis of PP2Cα/β expression in non-transfected: sc-117752 (A) and human PP2Cα/β transfected: sc-113626 (B) 293T whole cell lysates.

PP2Cα/β (H-300) - sc-48829 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PP2Ca/b (H-300): sc-48829. Western blot analysis of PP2Ca/b expression in non-transfected: sc-117752 (A) and human PP2Ca/b transfected: sc-113498 (B) 293T whole cell lysates.

Anti-PPM1A antibody - ab154489 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PPM1A antibody (ab154489) at 1/1000 dilutionLane 1 : 293T whole cell lysateLane 2 : A431 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-PPM1A antibody - ab60237 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab60237 (1/50-1/100) staining human PPM1A in human breast carcinoma tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma

Anti-PPM1A antibody [4E11] - ab124353 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4E11
ab124353, at 5ug/ml, staining PPM1A in formalin-fixed, paraffin-embedded Human liver tissue by Immunohistochemistry.

Anti-PPM1A antibody [7F12] - ab135249 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7F12
ELISA analysis using ab135249 with different concentrations of antigen.

Anti-PPM1A antibody [EP1684Y] - ab76574 from Abcam

Prices $391.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1684Y
Anti-PPM1A antibody [EP1684Y] (ab76574) at 1/2000 dilution + SH-SY5Y cell lysate at 10 µgSecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-PPM1A antibody [p6c7] - ab14824 from Abcam

Prices $400.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone p6c7

Anti-PPM1A / PP2CA Antibody (clone 7F12) - LS-C169090 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 7F12
Western blot using PPM1A monoclonal antibody against HEK293 (1) and PPM1A (AA: 202-382)-hIgGFc transfected HEK293 (2) cell lysate.

Anti-PPM1A / PP2CA Antibody (aa1-324) - LS-C131252 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PPM1A / PP2CA Antibody (AP) - LS-C216909 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1A / PP2CA Antibody (APC) - LS-C216910 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1A / PP2CA Antibody (FITC) - LS-C216911 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1A / PP2CA Antibody (Biotin) - LS-C216912 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1A / PP2CA Antibody (Azide-free, HRP) - LS-C216913 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1A / PP2CA Antibody (PE) - LS-C216915 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1A / PP2CA Antibody - LS-C329997 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1A / PP2CA Antibody (aa107-156) - LS-C112121 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PPM1A antibody LS-C112121 Western blot of Fetal Heart lysate.

Anti-PPM1A / PP2CA Antibody (aa1-324, clone 498922) - LS-C346447 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 498922
Detection of Human, Mouse, and Rat PP2C alpha/PPM1A by Western Blot. Western blot shows lysates of MCF-7 human breast cancer cell line, Neuro-2A mouse neuroblastoma cell line, and Rat-2 rat embryonic fibroblast cell line. PVDF Membrane was probed with 1 ug/mL of Mouse Anti-Human/Mouse/Rat PP2C alpha/PPM1A Monoclonal Antibody followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody. A specific band was detected for PP2C alpha/PPM1A at approximately 41 kDa (as indicated). This experiment was conducted under reducing conditions.

Anti-PPM1A / PP2CA Antibody (C-Terminus, clone EP1684Y) - LS-C50101 from LifeSpan Bioscience

Prices $490.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1684Y
IHC of paraffin-embedded human gastric carcinoma using anti-PP2C-alpha antibody
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