| Gene Symbol |
SLC17A3
|
| Entrez Gene |
10786
|
| Alt Symbol |
NPT4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 17 (organic anion transporter), member 3
|
| Other Description |
Na(+)/PI cotransporter 4|sodium-dependent phosphate transport protein 4|sodium/phosphate cotransporter 4|solute carrier family 17 (sodium phosphate), member 3
|
| Swissprots |
Q8WWC7 O00476 B7Z511 Q9H533 B7WNJ5
|
| Accessions |
EAW55495 EAW55496 EAW55497 O00476 AK296070 BAH12250 AK296082 BAH12253 AK298271 BAH12747 AK298297 BAH12751 AK298367 BAH12767 BC017952 AAH17952 BX107915 CB163247 DC340735 DC361549 DQ891991 ABM82917 DQ895181 ABM86107 U90545 AAB53423 Z83953 NM_001098486 NP_001091956 NM_006632 NP_006623
|
| Function |
Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.
|
| Subcellular Location |
Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level). {ECO:0000269|PubMed:20810651, ECO:0000269|PubMed:9149941}.
|
![Western Blot: SLC17A3 Overexpression Lysate (Adult Normal) [NBP2-08311] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLC17A3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/14519_SLC17A3%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08311-img0001.jpg)