Gene Symbol | SLC17A3 |
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Entrez Gene | 10786 |
Alt Symbol | NPT4 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 17 (organic anion transporter), member 3 |
Other Description | Na(+)/PI cotransporter 4|sodium-dependent phosphate transport protein 4|sodium/phosphate cotransporter 4|solute carrier family 17 (sodium phosphate), member 3 |
Swissprots | Q8WWC7 O00476 B7Z511 Q9H533 B7WNJ5 |
Accessions | EAW55495 EAW55496 EAW55497 O00476 AK296070 BAH12250 AK296082 BAH12253 AK298271 BAH12747 AK298297 BAH12751 AK298367 BAH12767 BC017952 AAH17952 BX107915 CB163247 DC340735 DC361549 DQ891991 ABM82917 DQ895181 ABM86107 U90545 AAB53423 Z83953 NM_001098486 NP_001091956 NM_006632 NP_006623 |
Function | Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport. |
Subcellular Location | Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level). {ECO:0000269|PubMed:20810651, ECO:0000269|PubMed:9149941}. |
SLC17A3 CRISPR/Cas9 KO Plasmid (h) - sc-411512 from Santa Cruz Biotechnology
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SLC17A3 HDR Plasmid (h) - sc-411512-HDR from Santa Cruz Biotechnology
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SLC17A3 Double Nickase Plasmid (h) - sc-411512-NIC from Santa Cruz Biotechnology
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SLC17A3 Double Nickase Plasmid (h2) - sc-411512-NIC-2 from Santa Cruz Biotechnology
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SLC17A3 CRISPR Activation Plasmid (h) - sc-411512-ACT from Santa Cruz Biotechnology
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SLC17A3 CRISPR Activation Plasmid (h2) - sc-411512-ACT-2 from Santa Cruz Biotechnology
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SLC17A3 Lentiviral Activation Particles (h) - sc-411512-LAC from Santa Cruz Biotechnology
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SLC17A3 Lentiviral Activation Particles (h2) - sc-411512-LAC-2 from Santa Cruz Biotechnology
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SLC17A3 siRNA (h) - sc-63040 from Santa Cruz Biotechnology
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SLC17A3 shRNA Plasmid (h) - sc-63040-SH from Santa Cruz Biotechnology
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SLC17A3 shRNA (h) Lentiviral Particles - sc-63040-V from Santa Cruz Biotechnology
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SLC17A3 RNAi - H00010786-R01 from Novus Biologicals
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MISSION® esiRNA - EHU090651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19436 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19436 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02223 from Sigma-Aldrich
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SLC17A3 siRNA (Human) - CRH7350 from Cohesion Biosciences
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SLC17A3 - MBS8204973 from MyBioSource
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shRNA set against Human SLC17A3 (NM_006632.3) - SHH408740 from Creative biogene
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shRNA set against Human SLC17A3(NM_006632.3) - SHR230226 from Creative biogene
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Human SLC17A3 siRNA - orb267852 from Biorbyt
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SLC17A3 shRNA Plasmid (Human) - CHH7350 from Cohesion Biosciences
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SLC17A3 miRNA 3'UTR clone - MiUTR1H-09449 from Creative biogene
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