| Gene Symbol |
KDM7A
|
| Entrez Gene |
80853
|
| Alt Symbol |
JHDM1D
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysine (K)-specific demethylase 7A
|
| Other Description |
histone lysine demethylase JHDM1D|jmjC domain-containing histone demethylation protein 1D|jumonji C domain containing histone demethylase 1 homolog D|jumonji C domain-containing histone demethylase 1 homolog D|lysine-specific demethylase 7|lysine-specific demethylase 7A
|
| Swissprots |
C9JQU2 Q9C0E5 Q6MZL8 A4D1S9 C9JJH9 Q6ZMT4
|
| Accessions |
AAS00360 EAL24032 EAW83940 Q6ZMT4 AB051505 BAB21809 AK057208 AK131497 BAD18641 BC127007 AAI27008 BX641017 CAE46011 BX649115 XM_011516586 XP_011514888 XM_011516587 XP_011514889 NM_030647 NP_085150
|
| Function |
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. {ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20194436, ECO:0000269|PubMed:20622853}.
|
| Subcellular Location |
Nucleus.
|