KDM7A

Gene Symbol KDM7A
Entrez Gene 80853
Alt Symbol JHDM1D
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 7A
Other Description histone lysine demethylase JHDM1D|jmjC domain-containing histone demethylation protein 1D|jumonji C domain containing histone demethylase 1 homolog D|jumonji C domain-containing histone demethylase 1 homolog D|lysine-specific demethylase 7|lysine-specific demethylase 7A
Swissprots C9JQU2 Q9C0E5 Q6MZL8 A4D1S9 C9JJH9 Q6ZMT4
Accessions AAS00360 EAL24032 EAW83940 Q6ZMT4 AB051505 BAB21809 AK057208 AK131497 BAD18641 BC127007 AAI27008 BX641017 CAE46011 BX649115 XM_011516586 XP_011514888 XM_011516587 XP_011514889 NM_030647 NP_085150
Function Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. {ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20194436, ECO:0000269|PubMed:20622853}.
Subcellular Location Nucleus.

JHDM1D CRISPR/Cas9 KO Plasmid (h) - sc-405142 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

JHDM1D HDR Plasmid (h) - sc-405142-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

JHDM1D Double Nickase Plasmid (h) - sc-405142-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

JHDM1D Double Nickase Plasmid (h2) - sc-405142-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

JHDM1D CRISPR Activation Plasmid (h) - sc-405142-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

JHDM1D CRISPR Activation Plasmid (h2) - sc-405142-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

JHDM1D Lentiviral Activation Particles (h) - sc-405142-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

JHDM1D Lentiviral Activation Particles (h2) - sc-405142-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

JHDM1D siRNA (h) - sc-89819 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

JHDM1D shRNA Plasmid (h) - sc-89819-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

JHDM1D shRNA (h) Lentiviral Particles - sc-89819-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU028631 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10864 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

KDM7A siRNA (Human) - CRJ2934 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human JHDM1D (NM_030647.1) - SHH322043 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human JHDM1D(NM_030647.1) - SHL186042 from Creative biogene

Category siRNA
Species Reactivities Human

KDM7A shRNA Plasmid (Human) - CHJ2934 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

JHDM1D miRNA 3'UTR clone - MiUTR1H-05064 from Creative biogene

Species Reactivities Human
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