KDM7A

Gene Symbol KDM7A
Entrez Gene 80853
Alt Symbol JHDM1D
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 7A
Other Description histone lysine demethylase JHDM1D|jmjC domain-containing histone demethylation protein 1D|jumonji C domain containing histone demethylase 1 homolog D|jumonji C domain-containing histone demethylase 1 homolog D|lysine-specific demethylase 7|lysine-specific demethylase 7A
Swissprots C9JQU2 Q9C0E5 Q6MZL8 A4D1S9 C9JJH9 Q6ZMT4
Accessions AAS00360 EAL24032 EAW83940 Q6ZMT4 AB051505 BAB21809 AK057208 AK131497 BAD18641 BC127007 AAI27008 BX641017 CAE46011 BX649115 XM_011516586 XP_011514888 XM_011516587 XP_011514889 NM_030647 NP_085150
Function Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. {ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20194436, ECO:0000269|PubMed:20622853}.
Subcellular Location Nucleus.

JHDM1D (N-13) - sc-135489 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
JHDM1D (N-13): sc-135489. Immunofluorescence staining of formalin-fixed HeLa cells showing nuclear and cytoplasmic localization. Kindly provided by Yang Xiang, Ph.D., Division of Newborn Medicine, Boston Childrens Hospital, Cell Biology Department, Harvard Medical School.

JHDM1D (S-15) - sc-135490 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
JHDM1D (S-15): sc-135490. Western blot analysis of JHDM1D expression in HeLa nuclear extract.

Anti-JHDM1D antibody - ab37905 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-JHDM1D antibody (ab37905) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 4 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 5 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLane 6 : A431 (Human epithelial carcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-JHDM1D antibody - ab119914 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-JHDM1D antibody (ab119914) at 1/1000 dilutionLane 1 : Human placenta lysateLane 2 : Human fetal spleen lysateLane 3 : Human fetal heart lysateLane 4 : Human fetal liver lysate

Anti-JHDM1D antibody - ab36044 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-JHDM1D antibody (ab36044) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-JHDM1D antibody - ab135028 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-JHDM1D antibody (ab135028) at 1/500 dilution + HeLa cell extract

Anti-KDM7A / JHDM1D Antibody (aa295-325, Biotin) - LS-C222937 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM7A / JHDM1D Antibody (aa295-325, AP) - LS-C222935 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM7A / JHDM1D Antibody (aa295-325, APC) - LS-C222936 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM7A / JHDM1D Antibody (aa295-325, FITC) - LS-C222938 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM7A / JHDM1D Antibody (aa295-325, Azide-free, HRP) - LS-C222939 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM7A / JHDM1D Antibody (aa295-325, PE) - LS-C222940 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM7A / JHDM1D Antibody (aa295-325) - LS-C329705 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM7A / JHDM1D Antibody (aa288-337) - LS-C112168 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
JHDM1D antibody LS-C112168 Western blot of MCF7 cell lysate.

Anti-KDM7A / JHDM1D Antibody (aa586-601) - LS-C178846 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KDM7A / JHDM1D Antibody (aa295-325) - LS-C165356 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
JHDM1D Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

JHDM1D Antibody - NBP1-81382 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: JHDM1D Antibody [NBP1-81382] - Staining of human cell line U-2 OS shows localization to nucleoplasm.

JHDM1D Antibody - NBP1-79714 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: JHDM1D Antibody [NBP1-79714] - MCF-7 whole cell lysates, concentration 0.2-1 ug/ml.

ANTI-JHDM1D (CENTER) antibody produced in rabbit - SAB1307185 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-JHDM1D (Center): <B>Cat. No. SAB1307185</B>: Western blot analysis of JHDM1D Antibody (Center) in 293 cell line lysates (35 μg/lane).

Anti-JHDM1D antibody produced in rabbit - SAB2101190 from Sigma-Aldrich

Prices $347.50
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-JHDM1D: <B>Cat. No.SAB2101190</B>: JHDM1D in MCF7 cell lysate with JHDM1D antibody at 1.0 μg/mL.

Anti-JHDM1D antibody produced in rabbit - HPA012114 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-JHDM1D: <B>Cat. No. HPA012114</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human cerebral cortex shows strong nuclear positivity in neuronal cells.

JHDM1D antibody - C region (ARP58206_P050) - ARP58206_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

JHDM1D Antibody - middle region (OAAB02533) - OAAB02533 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

JHDM1D-Antibody-Center - AP5116c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of JHDM1D Antibody (Center) (Cat. #AP5116c) in 293 cell line lysates (35ug/lane).JHDM1D (arrow) was detected using the purified Pab.

JHDM1D antibody, C-term - GTX44868 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
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