| Gene Symbol |
GAD2
|
| Entrez Gene |
2572
|
| Alt Symbol |
GAD65
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
|
| Other Description |
65 kDa glutamic acid decarboxylase|GAD-65|Glutamate decarboxylase-2 (pancreas)|glutamate decarboxylase 2|glutamate decarboxylase 65 kDa isoform
|
| Swissprots |
Q05329 Q9UD87
|
| Accessions |
AAP88040 EAW86101 EAW86102 EAW86103 EAW86104 Q05329 AJ251501 CAB62572 AK127375 BAC86947 BC029517 AAH29517 BC039038 BC047899 BC126327 AAI26328 BC126329 AAI26330 BI438818 BP392604 HQ258311 ADR83065 M74826 AAA58491 M81882 AAA62367 X69936 NM_000818 NP_000809 NM_001134366 NP_001127838
|
| Function |
Catalyzes the production of GABA.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:12356867}. Cytoplasmic vesicle {ECO:0000269|PubMed:12356867}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269|PubMed:12356867}; Lipid-anchor {ECO:0000269|PubMed:12356867}. Golgi apparatus membrane {ECO:0000269|PubMed:12356867}; Peripheral membrane protein {ECO:0000269|PubMed:12356867}; Cytoplasmic side {ECO:0000269|PubMed:12356867}. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
|
| Top Pathways |
Type I diabetes mellitus, GABAergic synapse, Taurine and hypotaurine metabolism, Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism
|