Gene Symbol | GAD2 |
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Entrez Gene | 2572 |
Alt Symbol | GAD65 |
Species | Human |
Gene Type | protein-coding |
Description | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) |
Other Description | 65 kDa glutamic acid decarboxylase|GAD-65|Glutamate decarboxylase-2 (pancreas)|glutamate decarboxylase 2|glutamate decarboxylase 65 kDa isoform |
Swissprots | Q05329 Q9UD87 |
Accessions | AAP88040 EAW86101 EAW86102 EAW86103 EAW86104 Q05329 AJ251501 CAB62572 AK127375 BAC86947 BC029517 AAH29517 BC039038 BC047899 BC126327 AAI26328 BC126329 AAI26330 BI438818 BP392604 HQ258311 ADR83065 M74826 AAA58491 M81882 AAA62367 X69936 NM_000818 NP_000809 NM_001134366 NP_001127838 |
Function | Catalyzes the production of GABA. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:12356867}. Cytoplasmic vesicle {ECO:0000269|PubMed:12356867}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269|PubMed:12356867}; Lipid-anchor {ECO:0000269|PubMed:12356867}. Golgi apparatus membrane {ECO:0000269|PubMed:12356867}; Peripheral membrane protein {ECO:0000269|PubMed:12356867}; Cytoplasmic side {ECO:0000269|PubMed:12356867}. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters. |
Top Pathways | Type I diabetes mellitus, GABAergic synapse, Taurine and hypotaurine metabolism, Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism |
GAD65 peptide (515-528) - ab45724 from Abcam
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Human GAD65 full length protein - ab114208 from Abcam
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Human GAD65 full length protein - ab158486 from Abcam
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GAD65 Antibody Blocking Peptide - LS-E762 from LifeSpan Bioscience
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GAD65 Antibody Blocking Peptide - LS-E25864 from LifeSpan Bioscience
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Recombinant Human GAD2/GAD65 Protein - H00002572-P02 from Novus Biologicals
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Recombinant Human GAD2/GAD65 Protein - H00002572-P03 from Novus Biologicals
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GAD2-Antibody-Center-Blocking-peptide - BP11118c from Abgent, a WuXi AppTec company
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GAD-65 protein - orb86025 from Biorbyt
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Goat anti GAD2 antibody Immunizing peptide - orb17110 from Biorbyt
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GAD65 (7897) peptide - orb71595 from Biorbyt
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Human GAD2 Protein - abx066816 from Abbexa
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GAD65 Peptide - AC21-0694-P from Abcore
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GAD2 / GAD65 - H00002572-P02 from Acris Antibodies
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GAD2 / GAD65 - H00002572-P02-10 from Acris Antibodies
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GAD2 / GAD65 - H00002572-P02-25 from Acris Antibodies
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GAD2 / GAD65 - H00002572-P03-10 from Acris Antibodies
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GAD2 / GAD65 - H00002572-P03-25 from Acris Antibodies
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Glutamate Decarboxylase 2, Acid (GAD2), Human - 20-7599 from ARP American Research Products
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Glutamate Decarboxylase 2, Acid (GAD2), Human - 20-7600 from ARP American Research Products
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Glutamate Decarboxylase 2, Acid (GAD2), Human - 20-7601 from ARP American Research Products
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GAD65 Peptide - 45-648P from ProSci
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GAD2 fusion protein - Ag16251 from Proteintech Group
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GAD2 fusion protein - ag17721 from Proteintech Group
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GAD65 (206 - 220) - 52632 from NeoScientific
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