Gene Symbol | ALKBH4 |
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Entrez Gene | 54784 |
Alt Symbol | ABH4 |
Species | Human |
Gene Type | protein-coding |
Description | alkB, alkylation repair homolog 4 (E. coli) |
Other Description | alkylated DNA repair protein alkB homolog 4|alpha-ketoglutarate-dependent dioxygenase alkB homolog 4|probable alpha-ketoglutarate-dependent dioxygenase ABH4 |
Swissprots | Q9NXW9 Q53H92 Q9H6A4 |
Accessions | CAK32306 EAW50249 Q9NXW9 AK000020 BAA90888 AK026097 BAB15358 AK222689 BAD96409 BC002820 AAH02820 BC017096 AAH17096 BX353099 CA420615 HQ447345 ADQ31831 XM_005250464 XP_005250521 XM_005250465 XP_005250522 NM_017621 NP_060091 |
Function | Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation. {ECO:0000269|PubMed:21166655, ECO:0000269|PubMed:23673617}. |
Subcellular Location | Cytoplasm. Nucleus. Midbody. Note=Associates with the contractile ring and midbody. |
Tissue Specificity | Widely expressed, with highest expression in pancreas, ovary and spleen. {ECO:0000269|PubMed:17979886}. |
ALKBH4 (A-15) - sc-244889 from Santa Cruz Biotechnology
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ALKBH4 (D-16) - sc-244888 from Santa Cruz Biotechnology
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Anti-ALKBH4 antibody - ab113500 from Abcam
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Anti-ALKBH4 Antibody (aa88-117, Biotin) - LS-C232556 from LifeSpan Bioscience
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Anti-ALKBH4 Antibody (aa88-117) - LS-C156283 from LifeSpan Bioscience
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Anti-ALKBH4 Antibody (aa88-117, AP) - LS-C232554 from LifeSpan Bioscience
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Anti-ALKBH4 Antibody (aa88-117, APC) - LS-C232557 from LifeSpan Bioscience
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Anti-ALKBH4 Antibody (aa88-117, PE) - LS-C232560 from LifeSpan Bioscience
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Anti-ALKBH4 Antibody (aa88-117, Azide-free, HRP) - LS-C249402 from LifeSpan Bioscience
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Anti-ALKBH4 Antibody (aa88-117, FITC) - LS-C232558 from LifeSpan Bioscience
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Anti-ALKBH4 Antibody - LS-C332055 from LifeSpan Bioscience
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Anti-ALKBH4 Antibody (aa95-125) - LS-C319434 from LifeSpan Bioscience
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Anti-ALKBH4 Antibody (aa38-282) - LS-C178537 from LifeSpan Bioscience
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ALKBH4 Antibody - NBP2-14737 from Novus Biologicals
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Anti-ALKBH4 antibody produced in rabbit - HPA051422 from Sigma-Aldrich
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ANTI-ALKBH4 (CENTER) antibody produced in rabbit - SAB1302428 from Sigma-Aldrich
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ALKBH4-Antibody-Center - AP12774c from Abgent, a WuXi AppTec company
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ALKBH4 Antibody - middle region (OAAB09055) - OAAB09055 from Aviva Systems Biology
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Anti -ALKBH4 (Alkylated DNA Repair Protein alkB Homolog 4, ABH4) - 209489 from USBiological Life Science
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Anti -ALKBH4, ID (ALKBH4, ABH4, Probable alpha-ketoglutarate-dependent dioxygenase ABH4,Alkylated DNA repair protein alkB homolog 4) - 031808 from USBiological Life Science
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Anti -ALKBH4, ID (ALKBH4, ABH4, Probable alpha-ketoglutarate-dependent dioxygenase ABH4,Alkylated DNA repair protein alkB homolog 4) (AP) - 031808-AP from USBiological Life Science
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Anti -ALKBH4, ID (ALKBH4, ABH4, Probable alpha-ketoglutarate-dependent dioxygenase ABH4,Alkylated DNA repair protein alkB homolog 4) (APC) - 031808-APC from USBiological Life Science
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Anti -ALKBH4, ID (ALKBH4, ABH4, Probable alpha-ketoglutarate-dependent dioxygenase ABH4,Alkylated DNA repair protein alkB homolog 4) (Azide free) (HRP) - 031808-HRP from USBiological Life Science
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Anti -ALKBH4, ID (ALKBH4, ABH4, Probable alpha-ketoglutarate-dependent dioxygenase ABH4,Alkylated DNA repair protein alkB homolog 4) (Biotin) - 031808-Biotin from USBiological Life Science
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Anti -ALKBH4, ID (ALKBH4, ABH4, Probable alpha-ketoglutarate-dependent dioxygenase ABH4,Alkylated DNA repair protein alkB homolog 4) (FITC) - 031808-FITC from USBiological Life Science
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