| Gene Symbol |
ALKBH4
|
| Entrez Gene |
54784
|
| Alt Symbol |
ABH4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
alkB, alkylation repair homolog 4 (E. coli)
|
| Other Description |
alkylated DNA repair protein alkB homolog 4|alpha-ketoglutarate-dependent dioxygenase alkB homolog 4|probable alpha-ketoglutarate-dependent dioxygenase ABH4
|
| Swissprots |
Q9NXW9 Q53H92 Q9H6A4
|
| Accessions |
CAK32306 EAW50249 Q9NXW9 AK000020 BAA90888 AK026097 BAB15358 AK222689 BAD96409 BC002820 AAH02820 BC017096 AAH17096 BX353099 CA420615 HQ447345 ADQ31831 XM_005250464 XP_005250521 XM_005250465 XP_005250522 NM_017621 NP_060091
|
| Function |
Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation. {ECO:0000269|PubMed:21166655, ECO:0000269|PubMed:23673617}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Midbody. Note=Associates with the contractile ring and midbody.
|
| Tissue Specificity |
Widely expressed, with highest expression in pancreas, ovary and spleen. {ECO:0000269|PubMed:17979886}.
|