MESDC2

Gene Symbol MESDC2
Entrez Gene 23184
Alt Symbol BOCA, MESD
Species Human
Gene Type protein-coding
Description mesoderm development candidate 2
Other Description LDLR chaperone MESD|mesoderm development protein|renal carcinoma antigen NY-REN-61
Swissprots B4DW84 Q969U1 Q14696 D3DW96
Accessions CAJ42747 EAW99109 EAW99110 Q14696 AI911839 AK026606 AK301416 BAG62946 AY359110 AAQ89468 BC007867 BC009210 AAH09210 BC012746 AAH12746 BE004295 D42039 BAA07640 DA938708 DB365572 LN608572 LN608574 NM_015154 NP_055969 NR_126327 NR_126328
Function Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. {ECO:0000269|PubMed:15014448, ECO:0000269|PubMed:17488095}.
Subcellular Location Endoplasmic reticulum {ECO:0000269|PubMed:15014448, ECO:0000269|PubMed:17488095}.

MESDC2 (C22F5) Rabbit mAb - 2763 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C22F5
Western blot analysis of extracts from various cell lines using MESDC2 (C22F5) Rabbit mAb.

MESDC2 (C-16) - sc-139398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
MESDC2 (C-16): sc-139398. Western blot analysis of MESDC2 expression in human liver tissue extract (A) and Jurkat (B) and K-562 (C) whole cell lysates.

MESDC2 (D-19) - sc-139397 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
MESDC2 (D-19): sc-139397. Western blot analysis of MESDC2 expression in non-transfected 293T: sc-117752 (A), mouse MESDC2 transfected 293T: sc-127144 (B), Jurkat (C), K-562 (D) and NIH/3T3 (E) whole cell lysates and mouse liver tissue extract (F).

MESDC2 (N-13) - sc-139396 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
MESDC2 (N-13): sc-139396. Western blot analysis of MESDC2 expression in non-transfected 293T: sc-117752 (A), mouse MESDC2 transfected 293T: sc-127144 (B) and Jurkat (C) whole cell lysates.

Anti-MESDC2 antibody - ab68809 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-MESDC2 antibody (ab68809) at 1/500 dilution + human liver lysate at 25 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-MESDC2 antibody - C-terminal - ab170504 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of 293 cells labeling MESDC2 with ab170504 at 1/10 followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green) and DAPI staining.

Anti-MESDC2 / MESD Antibody (aa206-234, AP) - LS-C263025 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MESDC2 / MESD Antibody (aa206-234, APC) - LS-C263026 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MESDC2 / MESD Antibody (aa206-234, Biotin) - LS-C263027 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MESDC2 / MESD Antibody (aa206-234, FITC) - LS-C263028 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MESDC2 / MESD Antibody (aa206-234, Azide-free, HRP) - LS-C263029 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MESDC2 / MESD Antibody (aa206-234, PE) - LS-C263030 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MESDC2 / MESD Antibody - LS-C308948 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-MESDC2 / MESD Antibody (aa203-234) - LS-C322961 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MESDC2 / MESD Antibody IHC-plus™ - LS-B5769 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Anti-MESDC2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5769 dilution 1:100.

Anti-MESDC2 / MESD Antibody (aa206-234) - LS-C164144 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MESDC2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

MESDC2 Antibody [Unconjugated] - AF5577 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of K562 human chronic myelogenous leukemia cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human MESDC2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5577) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for MESDC2 at approximately 26 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

MESDC2 Antibody (513802) - MAB5577 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 513802
Western blot shows lysates of Jurkat human acute T cell leukemia cell line and HeLa human cervical epithelial carcinoma cell line. PVDF Membrane was probed with 2 µg/mL of Human MESDC2 Monoclonal Antibody (Catalog # MAB5577) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for MESDC2 at approximately 29 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

MESDC2 Antibody - NBP2-30007 from Novus Biologicals

Prices $299.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

MESDC2 Antibody - NBP1-88555 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MESDC2 Antibody [NBP1-88555] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

MESDC2 Antibody - H00023184-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: MESDC2 Antibody [H00023184-B01P] - Analysis of MESDC2 expression in human liver.

Anti-MESDC2 antibody produced in mouse - SAB1400445 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-MESDC2, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1400445</B>: Antibody concentration: 1.0 ~ 5.0 μg/mL. Specific band of ~26.1 kDa using human liver lysate.

Anti-MESDC2 (51-65) antibody produced in rabbit - SAB1101596 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-MESDC2 (51-65) (RB): <B>Cat. No. SAB1101596</B>: Immunofluorescence of HUVEC cells using Anti-MESDC2 (51-65) (RB) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-MESDC2 (196-210) antibody produced in rabbit - SAB1101597 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-MESDC2 (196-210) (RB): <B>Cat. No. SAB1101597</B>: Immunofluorescence of HUVEC cells using Anti-MESDC2 (196-210) (RB) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-MESDC2 antibody produced in rabbit - HPA039414 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MESDC2: <B>Cat. No. HPA039414</B>: Immunohistochemical staining of human duodenum shows moderate cytoplasmic and nuclear positivity in glandular cells.
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