Gene Symbol | MESDC2 |
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Entrez Gene | 23184 |
Alt Symbol | BOCA, MESD |
Species | Human |
Gene Type | protein-coding |
Description | mesoderm development candidate 2 |
Other Description | LDLR chaperone MESD|mesoderm development protein|renal carcinoma antigen NY-REN-61 |
Swissprots | B4DW84 Q969U1 Q14696 D3DW96 |
Accessions | CAJ42747 EAW99109 EAW99110 Q14696 AI911839 AK026606 AK301416 BAG62946 AY359110 AAQ89468 BC007867 BC009210 AAH09210 BC012746 AAH12746 BE004295 D42039 BAA07640 DA938708 DB365572 LN608572 LN608574 NM_015154 NP_055969 NR_126327 NR_126328 |
Function | Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. {ECO:0000269|PubMed:15014448, ECO:0000269|PubMed:17488095}. |
Subcellular Location | Endoplasmic reticulum {ECO:0000269|PubMed:15014448, ECO:0000269|PubMed:17488095}. |
MESDC2 CRISPR/Cas9 KO Plasmid (h) - sc-406189 from Santa Cruz Biotechnology
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MESDC2 HDR Plasmid (h) - sc-406189-HDR from Santa Cruz Biotechnology
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MESDC2 Double Nickase Plasmid (h) - sc-406189-NIC from Santa Cruz Biotechnology
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MESDC2 Double Nickase Plasmid (h2) - sc-406189-NIC-2 from Santa Cruz Biotechnology
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MESDC2 CRISPR Activation Plasmid (h) - sc-406189-ACT from Santa Cruz Biotechnology
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MESDC2 CRISPR Activation Plasmid (h2) - sc-406189-ACT-2 from Santa Cruz Biotechnology
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MESDC2 Lentiviral Activation Particles (h) - sc-406189-LAC from Santa Cruz Biotechnology
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MESDC2 Lentiviral Activation Particles (h2) - sc-406189-LAC-2 from Santa Cruz Biotechnology
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MESDC2 siRNA (h) - sc-90278 from Santa Cruz Biotechnology
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MESDC2 shRNA Plasmid (h) - sc-90278-SH from Santa Cruz Biotechnology
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MESDC2 shRNA (h) Lentiviral Particles - sc-90278-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU020501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13211 from Sigma-Aldrich
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MESDC2 siRNA (Human) - CRH8065 from Cohesion Biosciences
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shRNA set against Human MESDC2 (NM_015154.1) - SHH340499 from Creative biogene
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shRNA set against Human MESDC2(NM_015154.1) - SHH185015 from Creative biogene
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Human MESDC2 siRNA - orb268567 from Biorbyt
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MESDC2 shRNA Plasmid (Human) - CHH8065 from Cohesion Biosciences
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MESDC2 miRNA 3'UTR clone - MiUTR1H-06211 from Creative biogene
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