NUDT16

Gene Symbol	NUDT16
Entrez Gene	131870
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	nudix (nucleoside diphosphate linked moiety X)-type motif 16
Other Description	IDP phosphatase|IDPase|U8 snoRNA-binding protein H29K|U8 snoRNA-decapping enzyme|inosine diphosphate phosphatase|m7GpppN-mRNA hydrolase|nucleoside diphosphate-linked moiety X motif 16|nudix motif 16
Swissprots	E9PED4 Q96N82 Q96DE0 B4E3B4 F5GYJ1
Accessions	EAW79210 Q96DE0 AK055827 BAB71024 AK091353 AK093567 AK295852 BAG58658 AK304650 BAG65426 BC009546 AAH09546 BC031215 AAH31215 BP199028 BP219080 CB121755 DC343245 NM_001171905 NP_001165376 NM_001171906 NP_001165377 NM_152395 NP_689608 NR_033268
Function	RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal- dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxygu
Subcellular Location	Nucleus. Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus. Cytoplasm. Note=Localized predominantly in the cytoplasm. Localized in nucleolus, and in a minor proportion in distinct foci in the nucleoplasm (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed strongly in lung, kidney, adrenal gland, testis, heart and brain. {ECO:0000269|PubMed:20385596}.
Top Pathways	RNA degradation, Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NUDT16 (D-16) - sc-103083 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-NUDT16 antibody - ab122947 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

NUDT16 Antibody - NBP2-37976 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

NUDT16 Antibody - NBP2-37992 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

NUDT16 antibody - 70R-18989 from Fitzgerald Prices $375.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

NUDT16 antibody - 12889-1-AP from Acris Antibodies Prices $270.00 Sizes 150 µl Host Rabbit Clonality Polyclonal

NUDT16 antibody - 12889-1-AP from Proteintech Group Prices $279.00 Sizes con: 20 μg/150μl Host Rabbit Clonality Polyclonal

Anti-NUDT16 monoclonal antibody - DCABH-16259 from Creative Diagnostics Host Rabbit Clonality Monoclonal

NUDT16, Polyclonal Antibody - MBS839126 from MyBioSource Prices $490.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

NUDT16 - A8860 from NeoScientific Prices $480.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

NUDT16 Polyclonal Antibody - A8860 from ABclonal Prices $200.00, $480.00 Sizes 50 µl, 200 µl Host Rabbit Clonality Polyclonal

Anti-NUDT16 antibody produced in rabbit - HPA062492 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Clonality Polyclonal

Anti-NUDT16 antibody produced in rabbit - HPA060452 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Clonality Polyclonal

NUDT16 Antibody - abx124878 from Abbexa Host Rabbit Clonality Polyclonal

anti-NUDT16 antibody - A005901 from Biobool Host Rabbit Clonality Polyclonal

NUDT16, Polyclonal Antibody - MBS7602134 from MyBioSource Prices $320.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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