Gene Symbol | NUDT16 |
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Entrez Gene | 131870 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | nudix (nucleoside diphosphate linked moiety X)-type motif 16 |
Other Description | IDP phosphatase|IDPase|U8 snoRNA-binding protein H29K|U8 snoRNA-decapping enzyme|inosine diphosphate phosphatase|m7GpppN-mRNA hydrolase|nucleoside diphosphate-linked moiety X motif 16|nudix motif 16 |
Swissprots | E9PED4 Q96N82 Q96DE0 B4E3B4 F5GYJ1 |
Accessions | EAW79210 Q96DE0 AK055827 BAB71024 AK091353 AK093567 AK295852 BAG58658 AK304650 BAG65426 BC009546 AAH09546 BC031215 AAH31215 BP199028 BP219080 CB121755 DC343245 NM_001171905 NP_001165376 NM_001171906 NP_001165377 NM_152395 NP_689608 NR_033268 |
Function | RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal- dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxygu |
Subcellular Location | Nucleus. Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus. Cytoplasm. Note=Localized predominantly in the cytoplasm. Localized in nucleolus, and in a minor proportion in distinct foci in the nucleoplasm (By similarity). {ECO:0000250}. |
Tissue Specificity | Expressed strongly in lung, kidney, adrenal gland, testis, heart and brain. {ECO:0000269|PubMed:20385596}. |
Top Pathways | RNA degradation, Purine metabolism |
Human NUDT16 full length protein - ab103059 from Abcam
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NUDT16 Antibody Blocking Peptide - LS-E19083 from LifeSpan Bioscience
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NUDT16 Recombinant Protein - H00131870-P01 from Novus Biologicals
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Recombinant Human NUDT16 Protein - NBP1-50952 from Novus Biologicals
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NUDT16 Protein (OPPA02576) - OPPA02576 from Aviva Systems Biology
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Human NUDT16 protein - orb168956 from Biorbyt
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NUDT16 protein (His tag) - 80R-1627 from Fitzgerald
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NUDT16 (1-195, His-tag) - AR09808PU-L from Acris Antibodies
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NUDT16 (1-195, His-tag) - AR09808PU-N from Acris Antibodies
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NUDT16 - H00131870-P01-10 from Acris Antibodies
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NUDT16 - H00131870-P01-25 from Acris Antibodies
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Nudix Type Motif 16, Human Recombinant - 228-12205-1 from RayBiotech
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NUDT16, 1-195aa, Human, His tag, E.coli - 01-1884-16 from ARP American Research Products
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NUDT16 fusion protein - Ag3925 from Proteintech Group
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NUDT16 Human - ENPS-060 from NeoScientific
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Recombinant Human NUDT16 - BP000682-ENZ-053 from Syd Labs
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NUDT16, 1-195aa, Recombinant Protein - GWB-P1170M from Genway Biotech
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Recombinant Human NUDT16, His-tagged - NUDT16-954H from Creative Biomart
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Recombinant Human NUDT16, His-tagged - NUDT16-1402H from Creative Biomart
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NUDT16 - JNV-087 from Reagent Proteins
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Recombinant Human U8 snoRNA-decapping enzyme(NUDT16) - CSB-YP850278HU CSB-EP850278HU CSB-BP850278HU CSB-MP850278HU from Cusabio
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NuDT16, 1-195aa, Human, His tag, E.coli - ATGP0868 from ATGen
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NUDT16 - TP306896 from Acris Antibodies
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Recombinant Human NUDT16 Protein, GST-tagged - NUDT16-151H from Creative Biomart
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Recombinant Human NUDT16 Protein, His-tagged - NUDT16-152H from Creative Biomart
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