NUDT16

Gene Symbol NUDT16
Entrez Gene 131870
Alt Symbol -
Species Human
Gene Type protein-coding
Description nudix (nucleoside diphosphate linked moiety X)-type motif 16
Other Description IDP phosphatase|IDPase|U8 snoRNA-binding protein H29K|U8 snoRNA-decapping enzyme|inosine diphosphate phosphatase|m7GpppN-mRNA hydrolase|nucleoside diphosphate-linked moiety X motif 16|nudix motif 16
Swissprots E9PED4 Q96N82 Q96DE0 B4E3B4 F5GYJ1
Accessions EAW79210 Q96DE0 AK055827 BAB71024 AK091353 AK093567 AK295852 BAG58658 AK304650 BAG65426 BC009546 AAH09546 BC031215 AAH31215 BP199028 BP219080 CB121755 DC343245 NM_001171905 NP_001165376 NM_001171906 NP_001165377 NM_152395 NP_689608 NR_033268
Function RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal- dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxygu
Subcellular Location Nucleus. Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus. Cytoplasm. Note=Localized predominantly in the cytoplasm. Localized in nucleolus, and in a minor proportion in distinct foci in the nucleoplasm (By similarity). {ECO:0000250}.
Tissue Specificity Expressed strongly in lung, kidney, adrenal gland, testis, heart and brain. {ECO:0000269|PubMed:20385596}.
Top Pathways RNA degradation, Purine metabolism

Human NUDT16 full length protein - ab103059 from Abcam

Category Protein
Source E. coli
Species Human
15% SDS-PAGE (3 µg)

NUDT16 Antibody Blocking Peptide - LS-E19083 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

NUDT16 Recombinant Protein - H00131870-P01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

Recombinant Human NUDT16 Protein - NBP1-50952 from Novus Biologicals

Category Protein
Prices $269.00, $729.00
Sizes 100 µg, 500 µg
Source E.coli
Species Human

NUDT16 Protein (OPPA02576) - OPPA02576 from Aviva Systems Biology

Category Protein
Prices $100.00
Sizes 5 µg
Source E. Coli

Human NUDT16 protein - orb168956 from Biorbyt

Category Protein
Prices $170.00, $289.00
Sizes 5 μg, 20 μg
Species Human

NUDT16 protein (His tag) - 80R-1627 from Fitzgerald

Category Protein
Prices $255.00
Sizes 100 µg
Source E.coli

NUDT16 (1-195, His-tag) - AR09808PU-L from Acris Antibodies

Category Protein
Prices $790.00
Sizes 500 µg
Source E. coli
Species Human
NUDT16

NUDT16 (1-195, His-tag) - AR09808PU-N from Acris Antibodies

Category Protein
Prices $340.00
Sizes 100 µg
Source E. coli
Species Human
NUDT16

NUDT16 - H00131870-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

NUDT16 - H00131870-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

Nudix Type Motif 16, Human Recombinant - 228-12205-1 from RayBiotech

Category Protein
Prices $118.00
Sizes 1 µg
Source Escherichia Coli.
Species Human

NUDT16, 1-195aa, Human, His tag, E.coli - 01-1884-16 from ARP American Research Products

Category Protein
Prices $179.00, $369.00, $849.00
Sizes 20 µg, 100 µg, 500 µg
Species Human

NUDT16 fusion protein - Ag3925 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, T-HIS
Species Human

NUDT16 Human - ENPS-060 from NeoScientific

Category Protein
Prices $65.00, $169.00, $3,510.00
Sizes 5 µg, 20 µg, 1 mg
Source Escherichia Coli.
Species Human

Recombinant Human NUDT16 - BP000682-ENZ-053 from Syd Labs

Category Protein
Prices $160.00, $2,700.00
Sizes 20 µg, 1 mg
Source E. coli-derived.
Species Human

NUDT16, 1-195aa, Recombinant Protein - GWB-P1170M from Genway Biotech

Category Protein
Prices $300.00, $900.00
Sizes 100 μg, 500 μg
Source E.coli
Species Human

Recombinant Human NUDT16, His-tagged - NUDT16-954H from Creative Biomart

Category Protein
Source E.coli.

Recombinant Human NUDT16, His-tagged - NUDT16-1402H from Creative Biomart

Category Protein
Source E.coli
Species Human

NUDT16 - JNV-087 from Reagent Proteins

Category Protein
Prices $364.00, $2,898.00
Sizes 20.00 µg, 1 mg
Source E.coli

Recombinant Human U8 snoRNA-decapping enzyme(NUDT16) - CSB-YP850278HU CSB-EP850278HU CSB-BP850278HU CSB-MP850278HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

NuDT16, 1-195aa, Human, His tag, E.coli - ATGP0868 from ATGen

Category Protein
Prices $80.00, $240.00, $720.00
Sizes 20 µg, 100 µg, 500 µg
Species Human
SDSPAGE

NUDT16 - TP306896 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
NUDT16

Recombinant Human NUDT16 Protein, GST-tagged - NUDT16-151H from Creative Biomart

Category Protein
Source E. coli
Species Human

Recombinant Human NUDT16 Protein, His-tagged - NUDT16-152H from Creative Biomart

Category Protein
Source E. coli
Species Human
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