| Gene Symbol |
NUDT16
|
| Entrez Gene |
131870
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nudix (nucleoside diphosphate linked moiety X)-type motif 16
|
| Other Description |
IDP phosphatase|IDPase|U8 snoRNA-binding protein H29K|U8 snoRNA-decapping enzyme|inosine diphosphate phosphatase|m7GpppN-mRNA hydrolase|nucleoside diphosphate-linked moiety X motif 16|nudix motif 16
|
| Swissprots |
E9PED4 Q96N82 Q96DE0 B4E3B4 F5GYJ1
|
| Accessions |
EAW79210 Q96DE0 AK055827 BAB71024 AK091353 AK093567 AK295852 BAG58658 AK304650 BAG65426 BC009546 AAH09546 BC031215 AAH31215 BP199028 BP219080 CB121755 DC343245 NM_001171905 NP_001165376 NM_001171906 NP_001165377 NM_152395 NP_689608 NR_033268
|
| Function |
RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal- dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxygu
|
| Subcellular Location |
Nucleus. Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus. Cytoplasm. Note=Localized predominantly in the cytoplasm. Localized in nucleolus, and in a minor proportion in distinct foci in the nucleoplasm (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed strongly in lung, kidney, adrenal gland, testis, heart and brain. {ECO:0000269|PubMed:20385596}.
|
| Top Pathways |
RNA degradation, Purine metabolism
|