| Gene Symbol |
MGMT
|
| Entrez Gene |
4255
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
O-6-methylguanine-DNA methyltransferase
|
| Other Description |
6-O-methylguanine-DNA methyltransferase|O-6-methylguanine-DNA-alkyltransferase|O6-methylguanine-DNA methyltransferase|methylated-DNA--protein-cysteine methyltransferase|methylguanine-DNA methyltransferase
|
| Swissprots |
Q5VY78 P16455
|
| Accessions |
AAD13867 AGQ03778 EAW49166 EAW49167 P16455 AK293593 BAG57059 BC000824 AAH00824 BI520029 BT006714 AAP35360 DC387686 DQ890723 ABM81649 DQ893901 ABM84827 KC249995 AGQ03777 M29971 AAA59596 M31767 AAA52317 M60761 AAA59594 X54228 CAA38137 XM_005252682 XP_005252739 XM_006717863 XP_006717926 XM_011539817 XP_011538119 NM_002412 NP_002403
|
| Function |
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
|
| Subcellular Location |
Nucleus.
|