| Gene Symbol |
SLC39A5
|
| Entrez Gene |
283375
|
| Alt Symbol |
LZT-Hs7, MYP24, ZIP5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 39 (zinc transporter), member 5
|
| Other Description |
solute carrier family 39 (metal ion transporter), member 5|solute carrier family 39 member 5|zinc transporter ZIP5|zrt- and Irt-like protein 5
|
| Swissprots |
B2R808 Q6ZMH5 Q8N6Y3
|
| Accessions |
EAW96916 EAW96917 EAW96918 Q6ZMH5 AK172768 BAD18751 AK298331 BAG60580 AK313188 BAG36005 BC027884 AAH27884 DA640935 DA918133 XM_005268803 XP_005268860 XM_011538198 XP_011536500 XM_011538199 XP_011536501 XM_011538200 XP_011536502 XM_011538201 XP_011536503 XM_011538202 XP_011536504 XR_944520 NM_001135195 NP_001128667 NM_173596 NP_775867
|
| Function |
May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status (By similarity). {ECO:0000250|UniProtKB:Q9D856, ECO:0000269|PubMed:24891338}.
|
| Subcellular Location |
Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed in liver, kidney, pancreas, small intestine, colon, spleen, fetal liver and fetal kidney. {ECO:0000269|PubMed:15322118}.
|
![Western Blot: SLC39A5 Overexpression Lysate (Adult Normal) [NBL1-16149] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLC39A5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/8711_SLC39A5%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-16149-img0002.jpg)