Gene Symbol | SLC39A5 |
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Entrez Gene | 283375 |
Alt Symbol | LZT-Hs7, MYP24, ZIP5 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 39 (zinc transporter), member 5 |
Other Description | solute carrier family 39 (metal ion transporter), member 5|solute carrier family 39 member 5|zinc transporter ZIP5|zrt- and Irt-like protein 5 |
Swissprots | B2R808 Q6ZMH5 Q8N6Y3 |
Accessions | EAW96916 EAW96917 EAW96918 Q6ZMH5 AK172768 BAD18751 AK298331 BAG60580 AK313188 BAG36005 BC027884 AAH27884 DA640935 DA918133 XM_005268803 XP_005268860 XM_011538198 XP_011536500 XM_011538199 XP_011536501 XM_011538200 XP_011536502 XM_011538201 XP_011536503 XM_011538202 XP_011536504 XR_944520 NM_001135195 NP_001128667 NM_173596 NP_775867 |
Function | May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status (By similarity). {ECO:0000250|UniProtKB:Q9D856, ECO:0000269|PubMed:24891338}. |
Subcellular Location | Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in liver, kidney, pancreas, small intestine, colon, spleen, fetal liver and fetal kidney. {ECO:0000269|PubMed:15322118}. |
ZIP5 CRISPR/Cas9 KO Plasmid (h) - sc-415309 from Santa Cruz Biotechnology
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ZIP5 HDR Plasmid (h) - sc-415309-HDR from Santa Cruz Biotechnology
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ZIP5 Double Nickase Plasmid (h) - sc-415309-NIC from Santa Cruz Biotechnology
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ZIP5 Double Nickase Plasmid (h2) - sc-415309-NIC-2 from Santa Cruz Biotechnology
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ZIP5 CRISPR Activation Plasmid (h) - sc-415309-ACT from Santa Cruz Biotechnology
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ZIP5 CRISPR Activation Plasmid (h2) - sc-415309-ACT-2 from Santa Cruz Biotechnology
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ZIP5 Lentiviral Activation Particles (h) - sc-415309-LAC from Santa Cruz Biotechnology
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ZIP5 Lentiviral Activation Particles (h2) - sc-415309-LAC-2 from Santa Cruz Biotechnology
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ZIP5 siRNA (h) - sc-95666 from Santa Cruz Biotechnology
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ZIP5 shRNA Plasmid (h) - sc-95666-SH from Santa Cruz Biotechnology
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ZIP5 shRNA (h) Lentiviral Particles - sc-95666-V from Santa Cruz Biotechnology
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SLC39A5 RNAi - H00283375-R01 from Novus Biologicals
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MISSION® esiRNA - EHU051391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19623 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19623 from Sigma-Aldrich
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SLC39A5 siRNA (Human) - CRJ6898 from Cohesion Biosciences
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SLC39A5 - MBS8200199 from MyBioSource
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shRNA set against Human SLC39A5 (NM_173596.2) - SHH411160 from Creative biogene
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Human SLC39A5 siRNA - orb277399 from Biorbyt
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SLC39A5 shRNA Plasmid (Human) - CHJ6898 from Cohesion Biosciences
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SLC39A5 miRNA 3'UTR clone - MiUTR4H-TG12476 from Creative biogene
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