CPSF6

Gene Symbol CPSF6
Entrez Gene 11052
Alt Symbol CFIM, CFIM68, HPBRII-4, HPBRII-7
Species Human
Gene Type protein-coding
Description cleavage and polyadenylation specific factor 6, 68kDa
Other Description CPSF 68 kDa subunit|cleavage and polyadenylation specificity factor 68 kDa subunit|cleavage and polyadenylation specificity factor subunit 6|cleavage factor Im complex 68 kDa subunit|pre-mRNA cleavage factor I, 68kD subunit|pre-mRNA cleavage factor Im (68kD)|pre-mRNA cleavage factor Im 68 kDa subunit|protein HPBRII-4/7
Swissprots Q53ES1 Q9BW18 Q16630 Q9BSJ7 A8K7K9
Accessions CAA47751 CCQ43384 EAW97215 EAW97216 EAW97217 EAW97218 EAW97219 Q16630 AK021534 AK021833 AK098338 AK223568 BAD97288 AK292024 BAF84713 AK299928 BAG61761 AW189370 BC000714 AAH00714 BC005000 AAH05000 DA365448 DQ892159 ABM83085 EU176688 ABW03489 X67337 CAA47752 XM_005268588 XP_005268645 XM_005268590 XP_005268647 NM_001300947 NP_001287876 NM_007007 NP_008938
Function Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping. {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.
Subcellular Location Nucleus {ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:9659921}. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.
Top Pathways mRNA surveillance pathway

Panoply™ Human CPSF6 Knockdown Stable Cell Line - CSC-DC003594 from Creative biogene

Category Cell Line
Species Human
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