| Gene Symbol |
CPSF6
|
| Entrez Gene |
11052
|
| Alt Symbol |
CFIM, CFIM68, HPBRII-4, HPBRII-7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cleavage and polyadenylation specific factor 6, 68kDa
|
| Other Description |
CPSF 68 kDa subunit|cleavage and polyadenylation specificity factor 68 kDa subunit|cleavage and polyadenylation specificity factor subunit 6|cleavage factor Im complex 68 kDa subunit|pre-mRNA cleavage factor I, 68kD subunit|pre-mRNA cleavage factor Im (68kD)|pre-mRNA cleavage factor Im 68 kDa subunit|protein HPBRII-4/7
|
| Swissprots |
Q53ES1 Q9BW18 Q16630 Q9BSJ7 A8K7K9
|
| Accessions |
CAA47751 CCQ43384 EAW97215 EAW97216 EAW97217 EAW97218 EAW97219 Q16630 AK021534 AK021833 AK098338 AK223568 BAD97288 AK292024 BAF84713 AK299928 BAG61761 AW189370 BC000714 AAH00714 BC005000 AAH05000 DA365448 DQ892159 ABM83085 EU176688 ABW03489 X67337 CAA47752 XM_005268588 XP_005268645 XM_005268590 XP_005268647 NM_001300947 NP_001287876 NM_007007 NP_008938
|
| Function |
Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping. {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:9659921}. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.
|
| Top Pathways |
mRNA surveillance pathway
|