| Gene Symbol |
COMMD6
|
| Entrez Gene |
170622
|
| Alt Symbol |
Acrg
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
COMM domain containing 6
|
| Other Description |
Acrg embryonic lethality minimal region ortholog|COMM domain-containing protein 6
|
| Swissprots |
A6NF28 Q7Z4G1 B7ZLN0 Q5TBK4
|
| Accessions |
EAW80539 EAW80540 EAW80541 Q7Z4G1 AA425275 AF086081 AF169971 AAQ13599 AK000009 AW516002 AY542161 AAS22243 BC110837 BC117391 AAI17392 BC143912 AAI43913 BC171758 AAI71758 BM476717 BX106312 BX538116 CD175553 DB487154 DB489071 DB509325 DB574884 HQ258699 ADR83450 HY028175 HY045286 HY105279 W94914 XM_011534948 XP_011533250 NM_001287392 NP_001274321 NM_001287393 NP_001274322 NM_001287394 NP_001274323 NM_203495 NP_987091 NM_203497 NP_987093
|
| Function |
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation. {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520, ECO:0000305|PubMed:21778237}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16573520, ECO:0000269|PubMed:21778237}. Cytoplasm {ECO:0000269|PubMed:16573520}.
|
| Tissue Specificity |
Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta. {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520}.
|
