Gene Symbol | COMMD6 |
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Entrez Gene | 170622 |
Alt Symbol | Acrg |
Species | Human |
Gene Type | protein-coding |
Description | COMM domain containing 6 |
Other Description | Acrg embryonic lethality minimal region ortholog|COMM domain-containing protein 6 |
Swissprots | A6NF28 Q7Z4G1 B7ZLN0 Q5TBK4 |
Accessions | EAW80539 EAW80540 EAW80541 Q7Z4G1 AA425275 AF086081 AF169971 AAQ13599 AK000009 AW516002 AY542161 AAS22243 BC110837 BC117391 AAI17392 BC143912 AAI43913 BC171758 AAI71758 BM476717 BX106312 BX538116 CD175553 DB487154 DB489071 DB509325 DB574884 HQ258699 ADR83450 HY028175 HY045286 HY105279 W94914 XM_011534948 XP_011533250 NM_001287392 NP_001274321 NM_001287393 NP_001274322 NM_001287394 NP_001274323 NM_203495 NP_987091 NM_203497 NP_987093 |
Function | May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation. {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520, ECO:0000305|PubMed:21778237}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:16573520, ECO:0000269|PubMed:21778237}. Cytoplasm {ECO:0000269|PubMed:16573520}. |
Tissue Specificity | Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta. {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520}. |
Human COMMD6 full length protein - ab183176 from Abcam
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COMMD6 protein (His tag) - 80R-3902 from Fitzgerald
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COMMD6 (1-85, His-tag) - AR51589PU-N from Acris Antibodies
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COMMD6 (1-85, His-tag) - AR51589PU-S from Acris Antibodies
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Recombinant Human COMM domain-containing protein 6(COMMD6) - CSB-YP772019HU CSB-EP772019HU CSB-BP772019HU CSB-MP772019HU from Cusabio
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COMMD6, 1-85aa, Human, His tag, E.coli - ATGP2769 from ATGen
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COMM domain containing 6 (COMMD6), transcript variant 2 (transcript variant 2) - TP316105 from Acris Antibodies
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COMMD6 Protein - NBP2-32520PEP from Novus Biologicals
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COMM Domain Containing 6 Protein (Recombinant) - abx261354 from Abbexa
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COMMD6 Peptide, Human - M34GP03486H from Creative Peptides
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Recombinant Human COMMD6 Protein - NBP2-51781 from Novus Biologicals
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COMMD6 fusion protein - Ag26778 from Proteintech Group
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COMMD6 - PAT-82768-1 from Nordic BioSite
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COMMD6 - PAT-82768-2 from Nordic BioSite
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COMM Domain Containing 6, Human Recombinant - 228-22159-1 from RayBiotech
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COMM Domain Containing 6, Recombinant Protein - MBS140942 from MyBioSource
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COMM domain-containing protein 6 (COMMD6), Recombinant Protein - MBS1380301 from MyBioSource
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COMMD6, Recombinant Protein - MBS206083 from MyBioSource
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COMMD6 fusion protein - Ag26805 from Proteintech Group
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