| Gene Symbol |
MAP2K3
|
| Entrez Gene |
5606
|
| Alt Symbol |
MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase 3
|
| Other Description |
MAP kinase kinase 3|MAPK/ERK kinase 3|MAPKK 3|MEK 3|SAPK kinase 2|dual specificity mitogen-activated protein kinase kinase 3|stress-activated protein kinase kinase 2
|
| Swissprots |
B3KSK7 P46734 Q9UE72 Q9UE71 Q99441
|
| Accessions |
AAB40653 EAW50386 P46734 AB451226 BAG70040 AB451349 BAG70163 AI758302 AK093838 BAG52769 AK223490 BAD97210 AK315505 BAG37889 BC032478 AAH32478 BM836867 CR536514 CAG38752 CR541793 CAG46592 D87116 BAA13248 DA131175 DA987047 DQ894188 ABM85114 GQ225578 ACT33197 L36719 AAC41718 U66839 AAB40652 XM_005256722 XP_005256779 XM_005256723 XP_005256780 XM_011523958 XP_011522260 XM_011523959 XP_011522261 NM_002756 NP_002747 NM_145109 NP_659731 NM_145110
|
| Function |
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
|
| Tissue Specificity |
Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
|
| Top Pathways |
Rap1 signaling pathway, Toll-like receptor signaling pathway, Inflammatory mediator regulation of TRP channels, TNF signaling pathway, Epstein-Barr virus infection
|