| Gene Symbol |
DHRS3
|
| Entrez Gene |
9249
|
| Alt Symbol |
DD83.1, RDH17, Rsdr1, SDR1, SDR16C1, retSDR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dehydrogenase/reductase (SDR family) member 3
|
| Other Description |
retinal short-chain dehydrogenase/reductase 1|retinol dehydrogenase 17|short chain dehydrogenase/reductase family 16C member 1|short chain dehydrogenase/reductase family 16C, member 1|short-chain dehydrogenase/reductase 1|short-chain dehydrogenase/reductase 3
|
| Swissprots |
Q6UY38 Q5VUY3 O75911 Q9BUC8 B2R7F3
|
| Accessions |
AAD55402 ABY58122 EAW71743 O75911 AF061741 AAC63263 AK222593 BAD96313 AK225057 AK309282 AK310202 AK312961 BAG35800 AL039062 AY358093 AAQ88460 BC002730 AAH02730 BF037805 BX648476 CAI46033 DQ426869 ABD90534 DQ426870 ABD90535 DQ893006 ABM83932 DQ896252 ABM87251 XM_005263533 XP_005263590 XM_005263534 XP_005263591 XM_006711036 XP_006711099 NM_004753 NP_004744
|
| Function |
Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH. {ECO:0000269|PubMed:9705317}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments. {ECO:0000269|PubMed:11861404, ECO:0000269|PubMed:9705317}.
|
| Top Pathways |
Retinol metabolism
|
