Gene Symbol | DHRS3 |
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Entrez Gene | 9249 |
Alt Symbol | DD83.1, RDH17, Rsdr1, SDR1, SDR16C1, retSDR1 |
Species | Human |
Gene Type | protein-coding |
Description | dehydrogenase/reductase (SDR family) member 3 |
Other Description | retinal short-chain dehydrogenase/reductase 1|retinol dehydrogenase 17|short chain dehydrogenase/reductase family 16C member 1|short chain dehydrogenase/reductase family 16C, member 1|short-chain dehydrogenase/reductase 1|short-chain dehydrogenase/reductase 3 |
Swissprots | Q6UY38 Q5VUY3 O75911 Q9BUC8 B2R7F3 |
Accessions | AAD55402 ABY58122 EAW71743 O75911 AF061741 AAC63263 AK222593 BAD96313 AK225057 AK309282 AK310202 AK312961 BAG35800 AL039062 AY358093 AAQ88460 BC002730 AAH02730 BF037805 BX648476 CAI46033 DQ426869 ABD90534 DQ426870 ABD90535 DQ893006 ABM83932 DQ896252 ABM87251 XM_005263533 XP_005263590 XM_005263534 XP_005263591 XM_006711036 XP_006711099 NM_004753 NP_004744 |
Function | Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH. {ECO:0000269|PubMed:9705317}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments. {ECO:0000269|PubMed:11861404, ECO:0000269|PubMed:9705317}. |
Top Pathways | Retinol metabolism |
DHRS3 CRISPR/Cas9 KO Plasmid (h) - sc-411259 from Santa Cruz Biotechnology
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DHRS3 HDR Plasmid (h) - sc-411259-HDR from Santa Cruz Biotechnology
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DHRS3 Double Nickase Plasmid (h) - sc-411259-NIC from Santa Cruz Biotechnology
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DHRS3 Double Nickase Plasmid (h2) - sc-411259-NIC-2 from Santa Cruz Biotechnology
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DHRS3 CRISPR Activation Plasmid (h) - sc-411259-ACT from Santa Cruz Biotechnology
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DHRS3 CRISPR Activation Plasmid (h2) - sc-411259-ACT-2 from Santa Cruz Biotechnology
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DHRS3 Lentiviral Activation Particles (h) - sc-411259-LAC from Santa Cruz Biotechnology
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DHRS3 Lentiviral Activation Particles (h2) - sc-411259-LAC-2 from Santa Cruz Biotechnology
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DHRS3 siRNA (h) - sc-78624 from Santa Cruz Biotechnology
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DHRS3 shRNA Plasmid (h) - sc-78624-SH from Santa Cruz Biotechnology
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DHRS3 shRNA (h) Lentiviral Particles - sc-78624-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU011311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7202 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7202 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03553 from Sigma-Aldrich
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DHRS3 siRNA (Human) - CRH6124 from Cohesion Biosciences
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DHRS3 RNAi - H00009249-R01 from Novus Biologicals
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DHRS3 - MBS8205256 from MyBioSource
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shRNA set against Human DHRS3 (NM_004753.4) - SHH277713 from Creative biogene
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shRNA set against Human DHRS3(NM_004753.4) - SHH003995 from Creative biogene
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Human DHRS3 siRNA - orb266626 from Biorbyt
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DHRS3 shRNA Plasmid (Human) - CHH6124 from Cohesion Biosciences
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DHRS3 miRNA 3'UTR clone - MiUTR1H-02812 from Creative biogene
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