RTF1

Gene Symbol	RTF1
Entrez Gene	23168
Alt Symbol	GTL7, KIAA0252
Species	Human
Gene Type	protein-coding
Description	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Other Description	RNA polymerase-associated protein RTF1 homolog|ortholog of mouse gene trap locus 7
Swissprots	Q96BX6 Q92541
Accessions	EAW92490 EAW92491 EAW92492 Q92541 AI871361 AK292302 BAF84991 AW291085 BC015052 AAH15052 BF979715 CD367287 D87440 BAA13382 NM_015138 NP_055953
Function	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
Subcellular Location	Nucleus, nucleoplasm {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RTF1 (D7V3W) Rabbit mAb - 14737 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D7V3W

RTF1 (C-17) - sc-324293 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-RTF1 antibody - ab129662 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RTF1 antibody [EPR13615] - ab184570 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR13615

Anti-RTF1 Antibody (aa325-375) - LS-C93407 from LifeSpan Bioscience Prices $545.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RTF1 Antibody (aa482-510, AP) - LS-C223972 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RTF1 Antibody (C-Terminus) - LS-C93408 from LifeSpan Bioscience Prices $545.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RTF1 Antibody (aa482-510, APC) - LS-C223974 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RTF1 Antibody (aa482-510, Biotin) - LS-C223975 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RTF1 Antibody (aa482-510, FITC) - LS-C223976 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RTF1 Antibody (aa482-510, Azide-free, HRP) - LS-C223977 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RTF1 Antibody (aa482-510, PE) - LS-C223978 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RTF1 Antibody (aa300-350) - LS-C287101 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RTF1 Antibody (aa620-670) - LS-C287102 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RTF1 Antibody (aa441-470) - LS-C324856 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RTF1 Antibody (aa482-510) - LS-C162800 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RTF1 Antibody (C-Terminus) - LS-C288139 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RTF1 Antibody - LS-C333394 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RTF1 Antibody (C-Terminus) - LS-C286519 from LifeSpan Bioscience Prices $415.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RTF1 Antibody - NB100-61052 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RTF1 Antibody - H00023168-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

RTF1 Antibody - NB600-278 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RTF1 Antibody - NB600-277 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RTF1 Polyclonal Antibody - bs-12261R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RTF1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12261R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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