RTF1

Gene Symbol RTF1
Entrez Gene 23168
Alt Symbol GTL7, KIAA0252
Species Human
Gene Type protein-coding
Description Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Other Description RNA polymerase-associated protein RTF1 homolog|ortholog of mouse gene trap locus 7
Swissprots Q96BX6 Q92541
Accessions EAW92490 EAW92491 EAW92492 Q92541 AI871361 AK292302 BAF84991 AW291085 BC015052 AAH15052 BF979715 CD367287 D87440 BAA13382 NM_015138 NP_055953
Function Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
Subcellular Location Nucleus, nucleoplasm {ECO:0000250}.

RTF1 CRISPR/Cas9 KO Plasmid (h) - sc-409519 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RTF1 HDR Plasmid (h) - sc-409519-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RTF1 Double Nickase Plasmid (h) - sc-409519-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RTF1 Double Nickase Plasmid (h2) - sc-409519-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RTF1 CRISPR Activation Plasmid (h) - sc-409519-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RTF1 CRISPR Activation Plasmid (h2) - sc-409519-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RTF1 Lentiviral Activation Particles (h) - sc-409519-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RTF1 Lentiviral Activation Particles (h2) - sc-409519-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RTF1 siRNA (h) - sc-89916 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RTF1 shRNA Plasmid (h) - sc-89916-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RTF1 shRNA (h) Lentiviral Particles - sc-89916-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU035981 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18730 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18730 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11860 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11860

RTF1 siRNA (Human) - CRH8051 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RTF1 - MBS8235269 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RTF1 (NM_015138.4) - SHH400464 from Creative biogene

Category siRNA
Species Reactivities Human

Human RTF1 siRNA - orb268553 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RTF1 shRNA Plasmid (Human) - CHH8051 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RTF1 miRNA 3'UTR clone - MiUTR4H-TG12397 from Creative biogene

Species Reactivities Human
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