| Gene Symbol |
RTF1
|
| Entrez Gene |
23168
|
| Alt Symbol |
GTL7, KIAA0252
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
|
| Other Description |
RNA polymerase-associated protein RTF1 homolog|ortholog of mouse gene trap locus 7
|
| Swissprots |
Q96BX6 Q92541
|
| Accessions |
EAW92490 EAW92491 EAW92492 Q92541 AI871361 AK292302 BAF84991 AW291085 BC015052 AAH15052 BF979715 CD367287 D87440 BAA13382 NM_015138 NP_055953
|
| Function |
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000250}.
|