RTF1

Gene Symbol	RTF1
Entrez Gene	23168
Alt Symbol	GTL7, KIAA0252
Species	Human
Gene Type	protein-coding
Description	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Other Description	RNA polymerase-associated protein RTF1 homolog|ortholog of mouse gene trap locus 7
Swissprots	Q96BX6 Q92541
Accessions	EAW92490 EAW92491 EAW92492 Q92541 AI871361 AK292302 BAF84991 AW291085 BC015052 AAH15052 BF979715 CD367287 D87440 BAA13382 NM_015138 NP_055953
Function	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
Subcellular Location	Nucleus, nucleoplasm {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RTF1 full length protein - ab161557 from Abcam Category Protein Source Wheat germ Species Human

RTF1 Antibody Blocking Peptide - LS-E4284 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RTF1 Protein - H00023168-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RTF1-Antibody-Center-Blocking-Peptide - BP16561c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RTF1 - H00023168-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RTF1 - H00023168-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RTF1 fusion protein - ag8285 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli-derived, PET28a Species Human

RTF1 fusion protein - ag2812 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human RTF1, His-tagged - RTF1-2459H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human RNA polymerase-associated protein RTF1 homolog(RTF1) - CSB-YP821675HU CSB-EP821675HU CSB-BP821675HU CSB-MP821675HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RTF1 Recombinant Protein Antigen - NBP1-83019PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RTF1 Antibody - SH-A15405 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse, Rat

RTF1 Peptide, Human - M34GP13667H from Creative Peptides Category Peptide Source Synthetic. Species Human

RNA polymerase-associated protein RTF1 homolog (RTF1), Recombinant Protein - MBS1396262 from MyBioSource Category Protein Prices $1,515.00, $1,515.00, $1,745.00, $1,745.00, $2,600.00, $2,600.00, $3,040.00, $3,040.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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