| Gene Symbol |
TWIST1
|
| Entrez Gene |
7291
|
| Alt Symbol |
ACS3, BPES2, BPES3, CRS, CRS1, CSO, SCS, TWIST, bHLHa38
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
twist family bHLH transcription factor 1
|
| Other Description |
B-HLH DNA binding protein|H-twist|TWIST homolog of drosophila|class A basic helix-loop-helix protein 38|twist basic helix-loop-helix transcription factor 1|twist homolog 1|twist-related protein 1
|
| Swissprots |
Q99804 Q92487 A4D128 Q15672
|
| Accessions |
AAC50930 AAC60381 CAA62850 CAA71821 EAL24279 EAW93711 Q15672 AW173505 BC036704 AAH36704 DQ896770 ABM87769 X99268 CAA67664 Y11177 Y11178 XM_011515496 XP_011513798 NM_000474 NP_000465
|
| Function |
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Subset of mesodermal cells.
|
| Top Pathways |
Proteoglycans in cancer
|