TWIST1

Gene Symbol TWIST1
Entrez Gene 7291
Alt Symbol ACS3, BPES2, BPES3, CRS, CRS1, CSO, SCS, TWIST, bHLHa38
Species Human
Gene Type protein-coding
Description twist family bHLH transcription factor 1
Other Description B-HLH DNA binding protein|H-twist|TWIST homolog of drosophila|class A basic helix-loop-helix protein 38|twist basic helix-loop-helix transcription factor 1|twist homolog 1|twist-related protein 1
Swissprots Q99804 Q92487 A4D128 Q15672
Accessions AAC50930 AAC60381 CAA62850 CAA71821 EAL24279 EAW93711 Q15672 AW173505 BC036704 AAH36704 DQ896770 ABM87769 X99268 CAA67664 Y11177 Y11178 XM_011515496 XP_011513798 NM_000474 NP_000465
Function Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250}.
Subcellular Location Nucleus.
Tissue Specificity Subset of mesodermal cells.
Top Pathways Proteoglycans in cancer

TWIST1 Antibody - 4119 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

twist (H-81) - sc-15393 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
twist (H-81): sc-15393. Western blot analysis of twist expression in HeLa nuclear extract (A) and WI 38 (B), AtT-20/D16vF2 (C), JAR (D), MES-SA/Dx5 (E) and JEG-3 (F) whole cell lysates

twist (Twist2C1a) - sc-81417 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
VAX2 (VAX2A8F12): sc-81422 Western Blot analysis of VAX2 expression in NIH/3T3 whole cell lysate.

twist (C-17) - sc-6269 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
twist (C-17): sc-6269. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pre-menopausal uterus tissue showing cytoplasmic staining of glandular cells.

twist (N-19) - sc-6070 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

twist (L-21) - sc-134136 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
twist (L-21): sc-134136. Western blot analysis of twist expression in Jurkat whole cell lysate.

Anti-Twist antibody - ab50581 from Abcam

Prices $400.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Human melanoma Mel15 cells were fixed and permeabilized with 4% paraformaldehyde followed by 0.1% Triton X-100. Fixed cells were stained with 2 µg/ml ab50581. The antibody was developed with Goat Anti-Rabbit IgG, Cy3 conjugate.

Anti-Twist antibody - ab49254 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Twist antibody (ab49254) at 2.5 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50,000 - 1/100,000

Anti-Twist antibody - ab73136 from Abcam

Prices $372.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Twist antibody [10E4E6] - ab175430 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10E4E6
All lanes : Anti-Twist antibody [10E4E6] (ab175430) at 1/500 dilutionLane 1 : HEK293 cell lysateLane 2 : Twist (aa9-74) - hIgGFc transfected HEK293 cell lysate

Anti-Twist antibody [2F8E7] - ab140658 from Abcam

Host Mouse
Clonality Monoclonal
Clone 2F8E7
Anti-Twist antibody [2F8E7] (ab140658) at 1/500 dilution + Human Twist recombinant protein

Anti-Twist antibody [3E10] - ab135180 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E10

Anti-Twist antibody [Twist2C1a] - ChIP Grade - ab50887 from Abcam

Prices $403.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Twist2C1a
ChIP analysis using ab50887 binding Twist in Human primary macrophages. Cells were cross-linked for 15 minutes with formaldehyde. Samples were incubated with primary antibody  (1/100) for 12 hours at 4°C. Protein binding was detected using real-time PCR.See Abreview

Anti-TWIST1 / TWIST Antibody - LS-C93189 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TWIST1 / TWIST Antibody - LS-C76653 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-TWIST1 / TWIST Antibody (aa1-159, CF) - LS-C132779 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Sheep
Clonality Polyclonal

Anti-TWIST1 / TWIST Antibody (aa1-159, APC) - LS-C132778 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Sheep
Clonality Polyclonal

Anti-TWIST1 / TWIST Antibody (N-Terminus) - LS-C153587 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TWIST1 / TWIST Antibody (N-Terminus, clone 3E10) - LS-C153352 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E10

Anti-TWIST1 / TWIST Antibody - LS-C149825 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TWIST1 / TWIST Antibody (C-Terminus) - LS-C30601 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: Jurkat Cell Lysate

Anti-TWIST1 / TWIST Antibody (aa1-202) - LS-C182967 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-TWIST1 / TWIST Antibody - LS-C314086 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TWIST1 / TWIST Antibody (aa18-22) - LS-C205209 from LifeSpan Bioscience

Prices $265.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-TWIST1 / TWIST Antibody (N-Terminus) - LS-C145546 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TWIST1 / TWIST antibody LS-C145546 Western blot of Rat Liver lysate. Antibody concentration 1 ug/ml.
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