TWIST1

Gene Symbol	TWIST1
Entrez Gene	7291
Alt Symbol	ACS3, BPES2, BPES3, CRS, CRS1, CSO, SCS, TWIST, bHLHa38
Species	Human
Gene Type	protein-coding
Description	twist family bHLH transcription factor 1
Other Description	B-HLH DNA binding protein|H-twist|TWIST homolog of drosophila|class A basic helix-loop-helix protein 38|twist basic helix-loop-helix transcription factor 1|twist homolog 1|twist-related protein 1
Swissprots	Q99804 Q92487 A4D128 Q15672
Accessions	AAC50930 AAC60381 CAA62850 CAA71821 EAL24279 EAW93711 Q15672 AW173505 BC036704 AAH36704 DQ896770 ABM87769 X99268 CAA67664 Y11177 Y11178 XM_011515496 XP_011513798 NM_000474 NP_000465
Function	Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus.
Tissue Specificity	Subset of mesodermal cells.
Top Pathways	Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Twist full length protein - ab132349 from Abcam Category Protein Source Wheat germ Species Human

Human Twist peptide - ab111667 from Abcam Category Peptide Species Human

Human Twist peptide - ab58194 from Abcam Category Peptide

Human Twist protein fragment - ab112368 from Abcam Category Protein Source Wheat germ Species Human

Human Twist protein fragment - ab152775 from Abcam Category Protein Source Wheat germ Species Human

TWIST1 / TWIST Antibody Blocking Peptide - LS-E11805 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TWIST1 / TWIST Antibody Blocking Peptide - LS-E13630 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Twist-1 Protein - H00007291-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Twist-1 Protein - H00007291-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Twist-1 Protein - H00007291-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TWIST1-Antibody-Center-Blocking-Peptide - BP19501c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Twist1 Blocking Peptide - 33R-10428 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TWIST Blocking Peptide - abx063392 from Abbexa Category Peptide Species Human, Mouse, Rat

TWIST1 - H00007291-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TWIST1 - H00007291-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TWIST1 - H00007291-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TWIST1 - H00007291-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TWIST1 - H00007291-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

TWIST1 - H00007291-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TWIST1 - H00007291-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TWIST1 fusion protein - Ag21924 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

TWIST1 fusion protein - ag12700 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human TWIST1, GST-tagged - TWIST1-3494H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Twist Transcription Factor (TWIST) - RPC838Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

TWIST Blocking Peptide - CBP2198 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

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