| Gene Symbol |
FFAR3
|
| Entrez Gene |
2865
|
| Alt Symbol |
FFA3R, GPR41
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
free fatty acid receptor 3
|
| Other Description |
G protein-coupled receptor 41|G-protein coupled receptor 41
|
| Swissprots |
B2RWM8 O14843 Q14CM7
|
| Accessions |
AAB86711 O14843 AK290710 BAF83399 BC035657 AAH35657 BC113695 AAI13696 BC148269 AAI48270 DQ891235 ABM82161 DQ894419 ABM85345 EU432115 ABY87914 XM_011526858 XP_011525160 NM_005304 NP_005295
|
| Function |
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:18801738}; Multi-pass membrane protein {ECO:0000269|PubMed:18801738}.
|
| Tissue Specificity |
Highest level in adipose tissue, and lower expression across all tissues tested. Expressed in sympathetic ganglia. {ECO:0000269|PubMed:12496283, ECO:0000269|PubMed:21518883}.
|