FFAR3

Gene Symbol FFAR3
Entrez Gene 2865
Alt Symbol FFA3R, GPR41
Species Human
Gene Type protein-coding
Description free fatty acid receptor 3
Other Description G protein-coupled receptor 41|G-protein coupled receptor 41
Swissprots B2RWM8 O14843 Q14CM7
Accessions AAB86711 O14843 AK290710 BAF83399 BC035657 AAH35657 BC113695 AAI13696 BC148269 AAI48270 DQ891235 ABM82161 DQ894419 ABM85345 EU432115 ABY87914 XM_011526858 XP_011525160 NM_005304 NP_005295
Function G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of
Subcellular Location Cell membrane {ECO:0000269|PubMed:18801738}; Multi-pass membrane protein {ECO:0000269|PubMed:18801738}.
Tissue Specificity Highest level in adipose tissue, and lower expression across all tissues tested. Expressed in sympathetic ganglia. {ECO:0000269|PubMed:12496283, ECO:0000269|PubMed:21518883}.

GPR41 CRISPR/Cas9 KO Plasmid (h) - sc-402190 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR41 HDR Plasmid (h) - sc-402190-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR41 Double Nickase Plasmid (h) - sc-402190-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR41 Double Nickase Plasmid (h2) - sc-402190-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR41 CRISPR Activation Plasmid (h) - sc-402190-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR41 CRISPR Activation Plasmid (h2) - sc-402190-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR41 Lentiviral Activation Particles (h) - sc-402190-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR41 Lentiviral Activation Particles (h2) - sc-402190-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR41 siRNA (h) - sc-97148 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GPR41 shRNA Plasmid (h) - sc-97148-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GPR41 shRNA (h) Lentiviral Particles - sc-97148-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU107781 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8637 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8637 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04679 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04679

FFAR3 siRNA (Human) - CRH1924 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FFAR3/GPR41 RNAi - H00002865-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

FFAR3 - MBS8218871 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FFAR3 (NM_005304.3) - SHH294253 from Creative biogene

Category siRNA
Species Reactivities Human

Human FFAR3 siRNA - orb262426 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FFAR3 shRNA Plasmid (Human) - CHH1924 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FFAR3 miRNA 3'UTR clone - MiUTR3H-06295 from Creative biogene

Species Reactivities Human
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