FFAR3

Gene Symbol	FFAR3
Entrez Gene	2865
Alt Symbol	FFA3R, GPR41
Species	Human
Gene Type	protein-coding
Description	free fatty acid receptor 3
Other Description	G protein-coupled receptor 41|G-protein coupled receptor 41
Swissprots	B2RWM8 O14843 Q14CM7
Accessions	AAB86711 O14843 AK290710 BAF83399 BC035657 AAH35657 BC113695 AAI13696 BC148269 AAI48270 DQ891235 ABM82161 DQ894419 ABM85345 EU432115 ABY87914 XM_011526858 XP_011525160 NM_005304 NP_005295
Function	G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18801738}; Multi-pass membrane protein {ECO:0000269|PubMed:18801738}.
Tissue Specificity	Highest level in adipose tissue, and lower expression across all tissues tested. Expressed in sympathetic ganglia. {ECO:0000269|PubMed:12496283, ECO:0000269|PubMed:21518883}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FFAR3 / GPR41 Antibody Blocking Peptide - LS-E7777 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FFAR3 / GPR41 Antibody Blocking Peptide - LS-E28397 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FFAR3-Antibody-C-term-Blocking-peptide - BP5222b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FFAR3 peptide - orb217358 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

GPR41 Blocking Peptide - abx062689 from Abbexa Category Peptide Species Human, Mouse, Rat

FFAR3 / GPR41 - H00002865-G01 from Acris Antibodies Category Protein Prices $440.00 Sizes 2 µg Species Human

FFAR3 fusion protein - ag5628 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Free Fatty Acid Receptor 3 (FFAR3) - RPA226Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Free Fatty Acid Receptor 3 (FFAR3) - RPA226Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

ChemiSCREEN™ Membrane Preparation Recombinant Human GPR41 Free Fatty Acid Receptor - HTS135M from EMD Millipore Prices $599.00 Sizes 200 units Species Human

GPR41 Blocking Peptide - CBP1495 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

GPR41 Peptide - BS5750P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human FFAR3/GPR41 Protein - H00002865-G01 from Novus Biologicals Category Protein Prices $415.00 Sizes 2 µg Source Wheat Germ Species Human

FFAR3/GPR41 Recombinant Protein Antigen - NBP2-14014PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FFAR3 Peptide, Human - M34GP05685H from Creative Peptides Category Peptide Source Synthetic. Species Human

Free fatty acid receptor 3 (FFAR3), Recombinant Protein - MBS1144854 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Free fatty acid receptor 3 (FFAR3), Recombinant Protein - MBS7014733 from MyBioSource Category Protein Prices $1,155.00, $2,140.00, $3,350.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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