FFAR3

Gene Symbol FFAR3
Entrez Gene 2865
Alt Symbol FFA3R, GPR41
Species Human
Gene Type protein-coding
Description free fatty acid receptor 3
Other Description G protein-coupled receptor 41|G-protein coupled receptor 41
Swissprots B2RWM8 O14843 Q14CM7
Accessions AAB86711 O14843 AK290710 BAF83399 BC035657 AAH35657 BC113695 AAI13696 BC148269 AAI48270 DQ891235 ABM82161 DQ894419 ABM85345 EU432115 ABY87914 XM_011526858 XP_011525160 NM_005304 NP_005295
Function G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of
Subcellular Location Cell membrane {ECO:0000269|PubMed:18801738}; Multi-pass membrane protein {ECO:0000269|PubMed:18801738}.
Tissue Specificity Highest level in adipose tissue, and lower expression across all tissues tested. Expressed in sympathetic ganglia. {ECO:0000269|PubMed:12496283, ECO:0000269|PubMed:21518883}.

GPR41 (L-13) - sc-131163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GPR41 (L-13): sc-131163. Western blot analysis of GPR41 expression in Jurkat (A) and human PBL (B) whole cell lysates.

GPR41 (E-12) - sc-131161 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GPR41 (H-100) - sc-98332 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GPR41 (H-100): sc-98332. Immunoperoxidase staining of formalin fixed, paraffin-embedded human upper stomach tissue showing cytoplasmic and membrane staining of glandular cells.

GPR41 (Y-13) - sc-131166 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-FFAR3 antibody - ab103718 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab103718 stained T24/83 cells.  The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab103718 at 5 µg/mL overnight at +4°C. The secondary antibody (green) was DyLight® 488 Goat anti-Rabbit IgG (H+L) (ab96899) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-FFAR3 antibody - ab150483 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human liver tissue labelling FFAR3 with ab150483 antibody at a concentration of 5 µg/ml.

Anti-FFAR3 / GPR41 Antibody (Internal) IHC-plus™ - LS-A1737 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FFAR3 antibody LS-A1737 IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-FFAR3 / GPR41 Antibody (aa11-60) - LS-C120654 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of LOVO cells, using FFAR3 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-FFAR3 / GPR41 Antibody (aa301-331, AP) - LS-C214198 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FFAR3 / GPR41 Antibody (aa12-61) - LS-C120975 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of MCF-7 cells, using GPR42 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-FFAR3 / GPR41 Antibody (aa301-331, APC) - LS-C214200 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FFAR3 / GPR41 Antibody (aa301-331, Biotin) - LS-C214201 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FFAR3 / GPR41 Antibody (aa301-331, Azide-free, HRP) - LS-C214202 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FFAR3 / GPR41 Antibody (aa301-331, PE) - LS-C214204 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FFAR3 / GPR41 Antibody (aa301-331, FITC) - LS-C214203 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FFAR3 / GPR41 Antibody (aa61-106) - LS-C313789 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FFAR3 / GPR41 Antibody (aa301-331) - LS-C329548 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FFAR3 / GPR41 Antibody (aa293-322) - LS-C166122 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of FFAR3 Antibody in Jurkat cell line lysates (35 ug/lane). FFAR3 (arrow) was detected using the purified antibody.

FFAR3/GPR41 Antibody - NBP2-14014 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: FFAR3/GPR41 Antibody [NBP2-14014] - Staining of human small intestine shows strong membranous and cytoplasmic positivity in glandular cells.

Anti-FFAR3, N-Terminal antibody produced in rabbit - SAB4501281 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-FFAR3, N-Terminal: <B>Cat. No. SAB4501281</B>: Immunofluorescence of LOVO cells using Anti-FFAR3, N-Terminal antibody. Cells on the left were treated with the Anti-FFAR3, N-Terminal antibody. Cells on the right (negative control) were treated with both Anti-FFAR3, N-Terminal antibody and the synthesized immunogen peptide.

Anti-FFAR3 antibody produced in rabbit - SAB2900477 from Sigma-Aldrich

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-FFAR3 (Internal), antibody produced in rabbit: <B>Cat. No. SAB2900477</B>: Anti-FFAR3 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

ANTI-FFAR3 (C-TERM) antibody produced in rabbit - SAB1303877 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-FFAR3 (C-term): <B>Cat. No. SAB1303877</B>: Western blot analysis of FFAR3 Antibody (C-term) in Jurkat cell line lysates (35 μg/lane).

Anti-FFAR3 antibody produced in rabbit - HPA044681 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-FFAR3:<B>Cat. No. HPA044681</B>: Immunohistochemical staining of human rectum shows strong cytoplasmic positivity in glandular cells.

FFAR3 Antibody - C-terminal region (OAAB02639) - OAAB02639 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

FFAR3-Antibody-C-term - AP5222b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of FFAR3 Antibody (C-term) (Cat. #AP5222b) in Jurkat cell line lysates (35ug/lane).FFAR3 (arrow) was detected using the purified Pab.
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