Gene Symbol | FGF19 |
---|---|
Entrez Gene | 9965 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | fibroblast growth factor 19 |
Other Description | FGF-19 |
Swissprots | O95750 |
Accessions | EAW74751 O95750 AB018122 BAA75500 AF110400 AAD45973 AY358302 AAQ88669 BC017664 AAH17664 BT006729 AAP35375 JF432499 ADZ15716 NM_005117 NP_005108 |
Function | Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. {ECO:0000269|PubMed:12815072, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:19085950}. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed in fetal brain, cartilage, retina, and adult gall bladder. {ECO:0000269|PubMed:10525310}. |
Top Pathways | Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton |