| Gene Symbol | PTP4A3 |
|---|---|
| Entrez Gene | 11156 |
| Alt Symbol | PRL-3, PRL-R, PRL3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase type IVA, member 3 |
| Other Description | potentially prenylated protein tyrosine phosphatase|protein tyrosine phosphatase type IVA 3|protein-tyrosine phosphatase 4a3|protein-tyrosine phosphatase of regenerating liver 3 |
| Swissprots | Q8IVN5 Q9BTW5 O75365 Q99849 |
| Accessions | EAW92231 O75365 AF041434 AAC29314 AI742376 AJ276554 CAC81757 AK311257 BC003105 AAH03105 BE778111 BQ637038 BT007303 AAP35967 U87168 AAB47560 XM_005250762 XP_005250819 XM_005250763 XP_005250820 XM_005250764 XP_005250821 XM_005250766 XP_005250823 XM_005250767 XP_005250824 XM_006716499 XP_006716562 XM_006716500 XP_006716563 XM_006725100 XP_006725163 XM_006725101 XP_006725164 XM_006725102 XP_006725165 XM_006725103 XP_006725166 XM_011516803 XP_011515105 XM_011516804 XP_011515106 XM_011516805 XP_011515107 XM_011546558 XP_011544860 XM_011546559 XP_011544861 XM_011546560 XP_011544862 XM_011546561 XP_011544863 NM_007079 NP_009010 NM_032611 NP_116000 |
| Function | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. {ECO:0000269|PubMed:11355880, ECO:0000269|PubMed:12782572}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12782572}. Early endosome {ECO:0000269|PubMed:12782572}. |
| Tissue Specificity | Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis. {ECO:0000269|PubMed:11355880}. |
PRL-3 CRISPR/Cas9 KO Plasmid (h) - sc-402331 from Santa Cruz Biotechnology
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PRL-3 HDR Plasmid (h) - sc-402331-HDR from Santa Cruz Biotechnology
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PRL-3 Double Nickase Plasmid (h) - sc-402331-NIC from Santa Cruz Biotechnology
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PRL-3 Double Nickase Plasmid (h2) - sc-402331-NIC-2 from Santa Cruz Biotechnology
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PRL-3 CRISPR Activation Plasmid (h) - sc-402331-ACT from Santa Cruz Biotechnology
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PRL-3 CRISPR Activation Plasmid (h2) - sc-402331-ACT-2 from Santa Cruz Biotechnology
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PRL-3 Lentiviral Activation Particles (h) - sc-402331-LAC from Santa Cruz Biotechnology
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PRL-3 Lentiviral Activation Particles (h2) - sc-402331-LAC-2 from Santa Cruz Biotechnology
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PRL-3 siRNA (h) - sc-39156 from Santa Cruz Biotechnology
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PRL-3 shRNA Plasmid (h) - sc-39156-SH from Santa Cruz Biotechnology
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PRL-3 shRNA (h) Lentiviral Particles - sc-39156-V from Santa Cruz Biotechnology
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PRL-3/PTP4A3 RNAi - H00011156-R01 from Novus Biologicals
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PRL-3/PTP4A3 RNAi - H00011156-R02 from Novus Biologicals
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MISSION® esiRNA - EHU152151 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0705 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1054 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0704 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0703 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17689 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17689 from Sigma-Aldrich
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PTP4A3 siRNA (Human) - CRH7637 from Cohesion Biosciences
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shRNA set against Human PTP4A3 (NM_007079.2) - SHH386340 from Creative biogene
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shRNA set against Human PTP4A3(NM_032611.1) - SHR151494 from Creative biogene
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shRNA set against Human PTP4A3(NM_007079.2) - SHR151496 from Creative biogene
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shRNA set against Human PTP4A3(NM_032611.1) - SHR151520 from Creative biogene
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