| Gene Symbol |
GAK
|
| Entrez Gene |
2580
|
| Alt Symbol |
DNAJ26, DNAJC26
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclin G associated kinase
|
| Other Description |
auxilin-2|cyclin-G-associated kinase
|
| Swissprots |
Q5U4P5 Q9BVY6 O14976
|
| Accessions |
EAW82644 EAW82645 EAW82646 O14976 AB208854 BAD92091 AK092587 AK097714 BAG53518 AK126735 BAC86662 AK127351 AK131464 BAD18609 AK299554 BAG61499 AK309413 BC000816 AAH00816 BC001290 BC008668 AAH08668 BC063606 AAH63606 BC085005 AAH85005 BC107076 AAI07077 BT007015 AAP35661 D88435 BAA22623 DA680073 XM_005272268 XP_005272325 XM_005272270 XP_005272327 XM_011513425 XP_011511727 XM_011513426 XP_011511728 XM_011513427 XP_011511729 XM_011513428 XP_011511730 XM_011513429 XP_011511731 XM_011513430 XP_011511732 XM_011513431 XP_011511733 XM_011513432 XP_011511734 XM_011513433 XP_011511735 XM_011513434 XP_011511736 NM_001286833 NP_001273762 NM_005255 NP_005246
|
| Function |
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. {ECO:0000269|PubMed:10625686}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:10625686}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:10625686}. Cell junction, focal adhesion {ECO:0000305|PubMed:10625686}. Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.
|
| Tissue Specificity |
Ubiquitous. Highest in testis.
|
![Western Blot: GAK Overexpression Lysate (Adult Normal) [NBL1-10941] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GAK.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3447_GAK%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10941-img0002.jpg)