| Gene Symbol |
MAP3K1
|
| Entrez Gene |
4214
|
| Alt Symbol |
MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
|
| Other Description |
MAP/ERK kinase kinase 1|MAPK/ERK kinase kinase 1|MEK kinase 1|mitogen-activated protein kinase kinase kinase 1
|
| Swissprots |
Q13233
|
| Accessions |
AAB05828 CCQ43342 Q13233 AA602425 AF042838 AAC97073 AK307828 BU194120 BX537527 DA889202 XM_005248519 XP_005248576 XM_011543406 XP_011541708 XM_011543407 XP_011541709 XM_011543408 XP_011541710 NM_005921 NP_005912
|
| Function |
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. {ECO:0000269|PubMed:9808624}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, GnRH signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, RIG-I-like receptor signaling pathway
|