MAP3K1

Gene Symbol MAP3K1
Entrez Gene 4214
Alt Symbol MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Other Description MAP/ERK kinase kinase 1|MAPK/ERK kinase kinase 1|MEK kinase 1|mitogen-activated protein kinase kinase kinase 1
Swissprots Q13233
Accessions AAB05828 CCQ43342 Q13233 AA602425 AF042838 AAC97073 AK307828 BU194120 BX537527 DA889202 XM_005248519 XP_005248576 XM_011543406 XP_011541708 XM_011543407 XP_011541709 XM_011543408 XP_011541710 NM_005921 NP_005912
Function Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. {ECO:0000269|PubMed:9808624}.
Top Pathways Ubiquitin mediated proteolysis, GnRH signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, RIG-I-like receptor signaling pathway

MEK kinase-1 (1-9C-2A) - sc-449 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MEK kinase-1 (1-9C-2A): sc-449. Western blot analysis of MEK kinase-1 expression in A-431 whole cell lysate. Note cleaved MEK kinase-1 expression.

MEK kinase-1 (C-22) - sc-252 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MEK kinase-1 (C-22): sc-252. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse lymph node showing cytoplasmic localization.

MEK kinase-1 (F-11) - sc-17820 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MEK kinase-1 (F-11): sc-17820. Western blot analysis of cleaved MEK kinase-1 expression in A-431 (A), HeLa (B), HL-60 (C), A-10 (D) and MDCK (E) whole cell lysates.

MEK kinase-1 (S-18) - sc-49449 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MEK kinase-1 (S-18): sc-49449. Western blot analysis of MEK kinase-1 expression in 3T3-L1 whole cell lysate.

MEK kinase-1 (43-Y) - sc-437 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MEK kinase-1 (43-Y): sc-437. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse lymph node tissue showing cytoplasmic localization.

MEK kinase-1 (2-8B-5E) - sc-448 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of His-tagged human recombinant MEK kinase-1. Antibodies tested include MEK kinase-1 (2-8B-5E): sc-448 at 1.0 µg/ml (A), 0.1 µg/ml (B) and 0.01 µg/ml (C) and MEK kinase-1 (43-Y): sc-437 at 0.1 µg/ml (D).

MEK kinase-1 (P-19) - sc-49448 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MEK kinase-1 (P-19): sc-49448. Western blot analysis of MEK kinase-1 expression in non-transfected: sc-117752 (A) and mouse MEK kinase-1 transfected: sc-375230 (B) 293T whole cell lysates.

p-MEK kinase-1 (Thr 1402) - sc-130202 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-MEKK1 (phospho T1400) antibody - ab138662 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MEKK1 (phospho T1400) antibody (ab138662) at 1/500 dilution + extracts from Jurkat cells at 30 µg

Anti-MEKK1 antibody - ab55653 from Abcam

Prices $387.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55653 MEKK1 antibody at 1ug/ml.

Anti-MEKK1 antibody - ab69533 from Abcam

Prices $378.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MEKK1 antibody (ab69533) at 1/1000 dilutionLane 1 : Molecular weight markerLane 2 : Tissue lysates prepared from Rat liverLane 3 : Tissue lysates prepared from Mouse liver

Anti-MAP3K1 / MEKK1 Antibody (aa654-669) - LS-C16483 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K1 / MEKK1 Antibody - LS-C122117 from LifeSpan Bioscience

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K1 / MEKK1 Antibody (Trp197) - LS-C193126 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K1 / MEKK1 Antibody - LS-C212181 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K1 / MEKK1 Antibody (HRP) - LS-C212183 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K1 / MEKK1 Antibody (FITC) - LS-C212184 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K1 / MEKK1 Antibody (Biotin) - LS-C212185 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K1 / MEKK1 Antibody (aa181-230) - LS-C199218 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HeLa cells, using MAP3K1 Antibody. The sample on the right was incubated with synthetic peptide.

Anti-MAP3K1 / MEKK1 Antibody (aa1251-1300) - LS-C81277 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

Anti-MAP3K1 / MEKK1 Antibody (aa1193-1221, AP) - LS-C262548 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K1 / MEKK1 Antibody (aa1193-1221, APC) - LS-C262549 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K1 / MEKK1 Antibody (aa1193-1221, PE) - LS-C262551 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K1 / MEKK1 Antibody (phospho-Thr1383, AP) - LS-C262550 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K1 / MEKK1 Antibody (clone 2F6) - LS-C197670 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F6
Detection limit for recombinant GST tagged MAP3K1 is approximately 0.03 ng/ml as a capture antibody.
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