| Gene Symbol | UBA6 |
|---|---|
| Entrez Gene | 55236 |
| Alt Symbol | E1-L2, MOP-4, UBE1L2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin-like modifier activating enzyme 6 |
| Other Description | UBA6, ubiquitin-activating enzyme E1|monocyte protein 4|ubiquitin-activating enzyme 6|ubiquitin-activating enzyme E1-like 2|ubiquitin-activating enzyme E1-like protein 2|ubiquitin-like modifier-activating enzyme 6 |
| Swissprots | Q9H3T7 Q8N9E4 Q86TC7 A0AVT1 Q8N5T3 Q9NVC9 B2RAV3 Q4W5K0 Q86T78 A6N8M7 Q6UV21 |
| Accessions | A0AVT1 AAY40999 EAX05549 EAX05550 EAX05551 EAX05552 EAX05553 AB014773 BAB19785 AK001670 BAA91824 AK027020 AK094164 BAG52833 AK094969 BAC04463 AK314371 BAG37000 AL596839 AL832015 CAD89908 AL832458 CAD89959 AM392673 CAL37551 AW451445 AY359880 AAQ63403 BC031637 AAH31637 BC126484 AAI26485 BC126486 AAI26487 BM973988 EF623993 ABR25253 XM_011532082 XP_011530384 NM_018227 NP_060697 |
| Function | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673}. |
| Tissue Specificity | Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759}. |
| Top Pathways | Ubiquitin mediated proteolysis |