UBA6

Gene Symbol UBA6
Entrez Gene 55236
Alt Symbol E1-L2, MOP-4, UBE1L2
Species Human
Gene Type protein-coding
Description ubiquitin-like modifier activating enzyme 6
Other Description UBA6, ubiquitin-activating enzyme E1|monocyte protein 4|ubiquitin-activating enzyme 6|ubiquitin-activating enzyme E1-like 2|ubiquitin-activating enzyme E1-like protein 2|ubiquitin-like modifier-activating enzyme 6
Swissprots Q9H3T7 Q8N9E4 Q86TC7 A0AVT1 Q8N5T3 Q9NVC9 B2RAV3 Q4W5K0 Q86T78 A6N8M7 Q6UV21
Accessions A0AVT1 AAY40999 EAX05549 EAX05550 EAX05551 EAX05552 EAX05553 AB014773 BAB19785 AK001670 BAA91824 AK027020 AK094164 BAG52833 AK094969 BAC04463 AK314371 BAG37000 AL596839 AL832015 CAD89908 AL832458 CAD89959 AM392673 CAL37551 AW451445 AY359880 AAQ63403 BC031637 AAH31637 BC126484 AAI26485 BC126486 AAI26487 BM973988 EF623993 ABR25253 XM_011532082 XP_011530384 NM_018227 NP_060697
Function Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673}.
Tissue Specificity Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759}.
Top Pathways Ubiquitin mediated proteolysis

UBE1L2/UBA6 Antibody - 13386 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using UBE1L2/UBA6 Antibody.

Anti-Uba6 antibody - ab118344 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-Uba6 antibody (ab118344) at 5 µg/ml + Immunogen peptide at 0.2 µg

Anti-Uba6 antibody - ab68196 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Uba6 antibody (ab68196) at 1/500 dilution + Human spleen tissue lysate at 25 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-Uba6 antibody - ab72091 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lanes 1 - 2 : Anti-Uba6 antibody (ab72091) at 1 µg/mlLane 3 : Anti-Uba6 antibody (ab72091) at 0.5 µg/mlLane 1 : Daudi cell lysateLane 2 : Daudi cell lysate plus immunizing peptideLane 3 : RAW cell lysate

Anti-UBE1L2 / UBE1L2 Antibody (aa860-889, AP) - LS-C242352 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L2 / UBE1L2 Antibody (aa860-889, APC) - LS-C242353 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L2 / UBE1L2 Antibody (aa860-889, Biotin) - LS-C242354 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L2 / UBE1L2 Antibody (aa860-889, FITC) - LS-C242355 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L2 / UBE1L2 Antibody (aa860-889, Azide-free, HRP) - LS-C247175 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L2 / UBE1L2 Antibody (aa860-889, PE) - LS-C242360 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L2 / UBE1L2 Antibody (aa601-650) - LS-C135516 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
UBA6 antibody LS-C135516 Western blot of HT1080 cell lysate.

Anti-UBE1L2 / UBE1L2 Antibody (aa860-889) - LS-C330271 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE1L2 / UBE1L2 Antibody (aa775-825) - LS-C148366 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of UBE1L2/MOP-4 in Daudi cell lysate in the 1) absence and 2) presence of immunizing peptide and 3) RAW using LS-C148366 at 1.0 ug/ml and 0.5 ug/ml respectively.

Anti-UBE1L2 / UBE1L2 Antibody (aa200-250) - LS-C290751 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse UBA6 by Western Blot. Samples: Whole cell lysate (50 ug) from 293T, HeLa, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-UBA6 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.

Anti-UBE1L2 / UBE1L2 Antibody (aa861-889) - LS-C160366 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
UBA6 Antibody western blot of K562 cell line lysates (35 ug/lane). The UBA6 antibody detected the UBA6 protein (arrow).

Anti-UBE1L2 / UBE1L2 Antibody (clone 1D11) IHC-plus™ - LS-B6351 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1D11
Anti-UBA6 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6351 concentration 5 ug/ml.

Anti-UBE1L2 / UBE1L2 Antibody (aa775-825) - LS-C290753 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse UBA6 by Western Blot. Samples: Whole cell lysate (50 ug) from 293T, HeLa, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-UBA6 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-UBE1L2 / UBE1L2 Antibody (aa1-50) - LS-C290752 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human UBA6 by Western Blot. Samples: Whole cell lysate (50 ug) from 293T, HeLa, and Jurkat cells. Antibodies: Affinity purified rabbit anti-UBA6 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-UBE1L2 / UBE1L2 Antibody (aa1002-1052) - LS-C290754 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human UBA6 by Western Blot. Samples: Whole cell lysate (50 ug) from 293T, HeLa, and Jurkat cells. Antibodies: Affinity purified rabbit anti-UBA6 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-UBE1L2 / UBE1L2 Antibody (aa300-350) IHC-plus™ - LS-B1816 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-UBA6 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1816 concentration 10 ug/ml.

FLJ10808 Antibody - NBP2-24587 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: FLJ10808 Antibody [NBP2-24587] - analysis of human UBA6 in Daudi cell lysate in the 1) absence and 2) presence of immunizing peptide and 3) RAW using UBA6 antibody at 2 ug/ml.

FLJ10808 Antibody - NBP2-24534 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: FLJ10808 Antibody [NBP2-24534] - Analysis of FLJ10808 in Daudi cell lysate in the 1) absence and 2) presence of immunizing peptide and 3) RAW using FLJ10808 antibody at 1.0 ug/ml and 0.5 ug/ml respectively.

FLJ10808 Antibody - NBP1-69106 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FLJ10808 Antibody [NBP1-69106] - Titration: 0.2-1 ug/ml, Positive Control: HT1080 cell lysate.

FLJ10808 Antibody - NBP1-87911 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FLJ10808 Antibody [NBP1-87911] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

FLJ10808 Antibody (1D11) - H00055236-M08 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D11
Immunocytochemistry/Immunofluorescence: FLJ10808 Antibody (1D11) [H00055236-M08] - Analysis of monoclonal antibody to UBA6 on HeLa cell. Antibody concentration 10 ug/ml
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