UBA6

Gene Symbol UBA6
Entrez Gene 55236
Alt Symbol E1-L2, MOP-4, UBE1L2
Species Human
Gene Type protein-coding
Description ubiquitin-like modifier activating enzyme 6
Other Description UBA6, ubiquitin-activating enzyme E1|monocyte protein 4|ubiquitin-activating enzyme 6|ubiquitin-activating enzyme E1-like 2|ubiquitin-activating enzyme E1-like protein 2|ubiquitin-like modifier-activating enzyme 6
Swissprots Q9H3T7 Q8N9E4 Q86TC7 A0AVT1 Q8N5T3 Q9NVC9 B2RAV3 Q4W5K0 Q86T78 A6N8M7 Q6UV21
Accessions A0AVT1 AAY40999 EAX05549 EAX05550 EAX05551 EAX05552 EAX05553 AB014773 BAB19785 AK001670 BAA91824 AK027020 AK094164 BAG52833 AK094969 BAC04463 AK314371 BAG37000 AL596839 AL832015 CAD89908 AL832458 CAD89959 AM392673 CAL37551 AW451445 AY359880 AAQ63403 BC031637 AAH31637 BC126484 AAI26485 BC126486 AAI26487 BM973988 EF623993 ABR25253 XM_011532082 XP_011530384 NM_018227 NP_060697
Function Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673}.
Tissue Specificity Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759}.
Top Pathways Ubiquitin mediated proteolysis

UBE1L2 CRISPR/Cas9 KO Plasmid (h) - sc-412489 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1L2 HDR Plasmid (h) - sc-412489-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1L2 Double Nickase Plasmid (h) - sc-412489-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1L2 Double Nickase Plasmid (h2) - sc-412489-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1L2 CRISPR Activation Plasmid (h) - sc-412489-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1L2 CRISPR Activation Plasmid (h2) - sc-412489-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1L2 Lentiviral Activation Particles (h) - sc-412489-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1L2 Lentiviral Activation Particles (h2) - sc-412489-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE1L2 siRNA (h) - sc-88898 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UBE1L2 shRNA Plasmid (h) - sc-88898-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UBE1L2 shRNA (h) Lentiviral Particles - sc-88898-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FLJ10808 RNAi - H00055236-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU043631 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1319 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1319 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

UBA6 siRNA (Human) - CRJ0583 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UBA6 - MBS8209171 from MyBioSource

UBA6 - MBS8210088 from MyBioSource

shRNA set against Human UBA6 (NM_018227.5) - SHH438696 from Creative biogene

Category siRNA
Species Reactivities Human

Human UBA6 siRNA - orb271084 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UBA6 shRNA Plasmid (Human) - CHJ0583 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UBA6 miRNA 3'UTR clone - MiUTR1H-10932 from Creative biogene

Species Reactivities Human
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